Table 1 Correlation between metrics from the selected biophysical dMRI approach with their direct histological counterparts

From: Clinically feasible liver tumour cell size measurement through histology-informed in vivo diffusion MRI

 

Histology \({{{{\boldsymbol{F}}}}}_{{{{\boldsymbol{histo}}}}}\)

Histology vCShisto

Histology CDhisto

Model Diff-in fitted to high b-value images

With \({F}_{{MRI}}\)

r = 0.19; p = 0.370

With \({{vCS}}_{{MRI}}\)

r = 0.44; p = 0.029

With \({{CD}}_{{MRI}}\)

r = 0.70; p = 0.00011

DKI ADC

r = –0.28; p = 0.180

r = 0.49; p = 0.014

r = –0.47; p = 0.017

DKI K

r = 0.40; p = 0.048

r = –0.31; p = 0.130

r = 0.43; p = 0.033

  1. The table reports Pearson’s correlation coefficients r and corresponding p-values p for dMRI metrics \({F}_{{MRI}}\) (intra-cellular fraction), \({vC}{S}_{{MRI}}\) (volume-weighted cell size index) and \(C{D}_{{MRI}}\) (cell density per unit volume) of model Diff-in, fitted to high b-value images. The correlations are reported between each MRI metric and its direct histological counterpart (\({F}_{{histo}}\) for \({F}_{{MRI}}\); \({vC}{S}_{{histo}}\) for \({vC}{S}_{{MRI}}\); and \(C{D}_{{histo}}\) for \(C{D}_{{MRI}}\)). For comparison, the table also reports correlation coefficients between routine ADC and K from DKI and each of \({F}_{{histo}}\), \({vC}{S}_{{histo}}\) and \(C{D}_{{histo}}\). The sample size was N = 25, implying that p < 0.05 if |r| > 0.396. p < 0.05 is flagged by bold font. The p-values were obtained from two-sided Pearson’s correlation tests, and are unadjusted for multiple comparisons.
Back to article page