Table 1 Sociodemographic and clinical characteristics of Florida Pancreas Collaborative participants with known cachexia status and baseline bloodb (n = 202)a

From: Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma

  

NCa (n = 81)

NCa %

Ca (n = 121)

Ca %

p-valuec

Age at diagnosis, mean (SD)d

 

68.6 (11.1)

 

69.0 (10.2)

 

0.826

Gendere

Female

52

64.20%

57

47.11%

0.025

 

Male

29

35.80%

64

52.89%

 

Race and Ethnicitye

Non-Hispanic Black

11

13.58%

19

15.70%

0.442

 

Hispanic/Latinx

13

16.05%

27

22.31%

 
 

Non-Hispanic White

57

70.37%

75

61.98%

 

Educatione

Post-graduate

19

23.46%

10

8.26%

0.003

 

Up to college

29

35.80%

31

25.62%

 
 

Up to high school

9

11.11%

28

23.14%

 
 

Missing

24

29.63%

52

42.98%

 

Incomee

$0-$60,000

17

20.99%

33

27.27%

0.298

 

$60,000-$100,000

15

18.52%

14

11.57%

 
 

Over $100,000

9

11.11%

12

9.92%

 
 

Missing

40

49.38%

62

51.24%

 

Insurance statuse

Insured

52

64.20%

69

57.02%

0.618

 

Uninsured

0

0.00%

2

1.65%

 
 

Missing

29

35.80%

50

41.32%

 

Marital Statuse

Married

42

51.85%

46

38.02%

0.138

 

Unmarried

12

14.81%

26

21.49%

 
 

Missing

27

33.33%

49

40.50%

 

Tumor Stagee

I/II

43

53.09%

50

41.32%

0.210

 

III/IV

26

32.10%

44

36.36%

 
 

Missing

12

14.81%

27

22.31%

 

Tumor Gradee

1 (well-diff)

3

3.70%

2

1.65%

0.759

 

2 (moderately diff)

25

30.86%

32

26.45%

 
 

3 (poorly diff)

14

17.28%

19

15.70%

 
 

4 (undifferentiated)

0

0.00%

0

0.00%

 
 

Missing

39

48.15%

68

56.20%

 

BMI Categorye

Underweight

5

6.17%

16

13.22%

0.021

 

Normal

20

24.69%

42

34.71%

 
 

Overweight

29

35.80%

43

35.54%

 
 

Obese

25

30.86%

18

14.88%

 
 

Missing

2

2.47%

2

1.65%

 

BMI, mean (SD)d

 

27.8 (5.4)

 

25.7 (5.0)

 

0.006

Family history of pancreatic cancere

No / Unknown

72

88.89%

119

98.35%

0.817

 

Yes

9

11.11%

2

1.65%

 

Smoking statuse

Never

31

38.27%

36

29.75%

0.117

 

Former

26

32.10%

37

30.58%

 
 

Current

2

2.47%

11

9.09%

 
 

Missing

22

27.16%

37

30.58%

 

Age-adjusted CCIe

0–5

13

16.05%

15

12.40%

0.597

 

>5

68

83.95%

106

87.60%

 
 

Missing

0

0.00%

0

0.00%

 

Diabetese

Yes

20

24.69%

46

38.02%

0.027

 

No

35

43.21%

53

43.80%

 
 

Missing

26

32.10%

22

18.18%

 

% Weight loss, median (SD)d

 

1.7 (2.8)

 

11.2 (5.3)

 

<0.0001

Waist circumf, median (SD)d

 

36.56 (6.2)

 

37.80 (15.4)

 

0.731

Waist-Hip Ratio, median (SD)d

 

0.92 (0.11)

 

0.92 (0.07)

 

0.360

ECOG performance statuse

0

53

65.43%

38

31.40%

<0.0001

 

1

25

30.86%

70

57.85%

 
 

2

1

1.23%

6

4.96%

 
 

3-4

0

0.00%

3

2.48%

 
 

Missing

2

2.47%

4

3.31%

 

Survival in days, median (LCI;UCI)

19.7 (15.1;38.8)

 

15.1 (13.3;17.8)

 

0.009

 
  1. P-values < 0.05 are in bold font.
  2. BMI Body Mass Index, Ca Cachectic, CCI Charlson Comorbidity Index, NCa Non-cachectic, LCI Lower confidence interval, UCI Upper confidence interval, SD standard deviation, circumf circumference
  3. a4 NHW patients with baseline blood (out of 206 total participants) could not be assessed for cachexia status due to missing weight values.
  4. bCachexia status according to Fearon et al. (31) with the following modification: skeletal mass index (SMI) was not assessed.
  5. cp-values were calculated based on non-missing values/groups only.
  6. dp-values represent a Wilcoxon ranked sum test (two-sided hypothesis).
  7. ep-values represent a chi square test (two-sided hypothesis).
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