Table 2 Statistical power to detect TACR3 rs74827081 associations in component analyses

Sample	Ancestry	N	Case rate	MAF	Power	Genome-wide significance for TACR3 locus
NHS + NHSII	European	24,424	0.63	0.06	~100%	yes
QIMR	European	545	0.63	0.06	0.01%	no
WHI	European	8185	0.63	0.06	90.93%	yes
	African	6732	0.77	0.01	0.15%	no
	Hispanic/Latina	2778	0.68	0.05	1.89%	no
UK Biobank	European	103,370	0.43	0.06	~100%	yes
	African	1357	0.17	0.01	0.00%	no
	South Asian	1713	0.24	0.02	0.00%	no
	East Asian	631	0.23	0.00	0.00%	no

At alpha=5 × 10⁻⁸, statistical power is a sufficient explanation for the pattern of significant and non-significant results for the TACR3 locus. For the East Asian sample in the UK Biobank, genotypes were not available, and so the frequency of this variant in gnomAD samples was used (i.e., minor allele frequency=0.0004).
NHS Nurses’ Health Study, NHSII Nurses’ Health Study II, QIMR Queensland Institute of Medical Research, WHI Women’s Health Initiative, MAF minor allele frequency.

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