Table 2 Top ROIs accounting for ~50% of the consistently highly-weighted connections (by FC edge count as well as by weight) in the classification model

From: Sparse machine learning of resting-state fMRI reveals brain-wide dysconnectivity in hyperacusis

ROI (1-414)

Part of network

Region

No. of highly-weighted FC edges

Co-ordinates [x, y, z]

Fraction of weight among consistently highly-weighted FC edges (%)

↑ trend in HA

↓ trend in HA

69

Dorsal Attention

Occipito-temporal/ fusiform

0

67

[-44, -42, -22]

13.49 %

201

2

44

[34, -36, -24]

8.952 %

7

Default mode

Parahippocampal cortex (PHC)

14

0

[-18, -38, -12]

1.941 %

106

Control & Salience

Anterior & Dorsolateral Prefrontal cortex

0

13

[-28, 44, 30]

1.794 %

138

0

18

[-28, 56, 12]

2.931 %

171

0

17

[-28, 58, 0]

3.002 %

342

8

6

[–6,42,50]

2.509 %

344

0

16

[6,40,50]

2.252 %

82

Dorsal Attention

Superior parietal lobule (SPL)

18

0

[-28, -62, 62]

2.089 %

277

0

12

[18, -78, 50]

1.255 %

319

Limbic

Orbitofrontal (OFC)

1

13

[–20,14,24]

2.548 %

Inferior temporal gyrus (ITG), Temporal poles

123

1

11

[-40, -22, -26]

1.919 %

326

0

14

[48, -6, -40]

2.347 %

330

11

1

[50, -28, -26]

2.405 %

411

Subcortex

Globus Pallidus, Nucleus Accumbens

16

3

[20, -4, -1]

3.05 %

414

8

5

[–6,8,11]

1.931 %

  1. ↑: increasing, ↓: decreasing.