Table 2 Individual cyst characteristics of all 222 (6 per subject) simple cysts, cysts with rapid growth vs. cysts with slow growth, small vs. big

From: Natural history of simple and complex cysts in autosomal dominant polycystic kidney disease on MRI

 

n (Cysts)

Left vs. Right

Interstitial vs.

Exophytic

% without

Transitioning

% Shrinking1

% Disappearing

% Transitioning

to Complex Cyst

On Index Scan

Diameter, d (mm)

Volume (mL)

All

222

111:111

148:74

58% (128)

29% (65)

16% (36)

6% (13)

25 [17, 38]

8 [3, 28]

Rapid growth2

(r > 10% per year)

107

43:64

70:37

82% (88)

8% (9)

8% (9)

2% (2)

22

[15, 33]

5

[2, 19]

Slow growth2

(r < 10% per year)

101

60:41

65:36

40% (40)

50% (51)

18% (18)

4% (4)

30

[20, 44]

15

[14, 43]

p-value

-

0.008**

0.89

< 0.001***

< 0.001***

0.06

0.43

< 0.001***

< 0.001***

Small (d < 2 cm)

81

38:43

62:19

56% (45)

25% (20)

26% (21)

7% (6)

15

[12, 18]

2

[1, 3]

Big (d > 2 cm)

141

73:68

86:55

59% (83)

32% (45)

11% (15)

5% (7)

34

[26, 44]

21

[9, 43]

p-value

-

0.58

0.02*

0.67

0.29

0.004**

0.55

-

-

  1. The percentages without transition, shriking, disappearing or transitioning to complex cysts refer to the entire period of imagnig follow-up, 8+ years. Fisher’s exact or χ² test for categorical data; Student’s t-test or Wilcoxon–Mann–Whitney U test for continuous data. All tests two-sided; no multiple-comparison adjustment. Exact p-values appear in the table. Data are % (n) or median [interquartile range].
  2. 1Cysts that shrink can also transition to complex cysts and/or disappear; 2Annual cyst growth rate cannot be calculated for 14 cysts due to lack of timepoints as simple cysts; *p < 0.05; **p < 0.01; ***p < 0.001 on univariate analysis.
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