Table 1 Associations of plasma proteins with incident coronary heart disease
Protein | Target | Cardiovascular Health Study (N = 2856 participants; N = 575 CHD events) | Atherosclerosis Risk in Communities Study (N = 10456 participants; N = 1375 CHD events) | ||
|---|---|---|---|---|---|
Hazard Ratio (95% CI) | P-value* | Hazard Ratio (95% CI) | P-value† | ||
Replicated Proteins | |||||
Cardiac troponin T | TNNT2 | 1.20 (1.12, 1.29) | 1.1 \(\times\)10-6 | 1.13 (1.07, 1.19) | 1.4 \(\times\)10-6 |
DnaJ homolog subfamily B member 9 | DNJB9 | 1.23 (1.13, 1.35) | 4.1 \(\times\)10-6 | 1.14 (1.08, 1.21) | 4.4\(\times\)10-6 |
Growth/differentiation factor 15 | GDF15 | 1.26 (1.14, 1.40) | 1.1 \(\times\)10-5 | 1.34 (1.26, 1.43) | 1.7 \(\times\)10-20 |
Liver-expressed antimicrobial peptide 2 | LEAP2 | 1.23 (1.12, 1.34) | 8.8 \(\times\)10-6 | 1.10 (1.04, 1.16) | 3.7 \(\times\)10-4 |
Macrophage metalloelastase | MMP12 | 1.31 (1.19, 1.44) | 1.8 \(\times\)10-8 | 1.35 (1.27, 1.43) | 9.2 \(\times\)10-24 |
N-terminal pro-BNP | NPPB | 1.29 (1.18, 1.42) | 5.4 \(\times\)10-8 | 1.13 (1.07, 1.20) | 6.7 \(\times\)10-6 |
Regenerating islet-derived protein 3-alpha | REG3A | 1.23 (1.12, 1.34) | 6.8 \(\times\)10-6 | 1.13 (1.07, 1.19) | 2.2 \(\times\)10-5 |
Vesicular, overexpressed in cancer, prosurvival protein 1 | VOPP1 | 0.80 (0.72, 0.88) | 1.3 \(\times\)10-5 | 0.87 (0.82, 0.93) | 4.8 \(\times\)10-5 |
Non-Replicated Proteins | |||||
ADP-ribosylation factor-like protein 5B | ARL5B | 1.19 (1.10, 1.28) | 6.4 \(\times\)10-6 | 1.08 (1.02, 1.14) | 0.005 |
CREB-binding protein | CREBBP | 1.18 (1.10, 1.28) | 1.6 \(\times\)10-5 | 1.03 (0.98, 1.09) | 0.27 |
Palmitoleoyl-protein carboxylesterase‡ | NOTUM | 0.90 (0.82, 0.98) | 0.02 | 0.98 (0.93, 1.03) | 0.40 |
