Fig. 2: Analysis of the human latent TGF-β1–SOF10Fab complex crystal structure.
From: Selective blockade of latent TGF-β1 activation suppresses tissue fibrosis with good safety
a Overall structure of human latent TGF-β1 in complex with SOF10 Fab. The latent TGF-β1 dimer is shown in surface view, with the LAP domain colored light pink and violet, mature TGF-β1 colored chartreuse and green, the latency lasso colored bright orange and orange, and the integrin binding site indicated in pale yellow and yellow. The SOF10 Fab fragment is shown as a cartoon, with the heavy chain colored marine and blue, and the light chain colored pale cyan and cyan. b Magnified view of the interaction between the CDR3 of the heavy chain in the SOF10 Fab and the surface of the latent TGF-β1 dimer. Interacting residues are shown as sticks, with at least one atom located within 3.5 Å of either the HCDR3 of the SOF10 Fab or latent TGF-β1.
