Extended Data Fig. 7: Sequence alignment of SidF with selected KSs.

These KSs are involved in the biosynthesis of metathramycin (MmyP, QVQ68799.1), rubrolone (RubE8, AOZ61212.1), kosinostati (KstA1, AFJ52674.1), chartreusin (ChaA, CAH10161.1), saprolmycin (SprD, BAV16999.1), enterocin (EncA, QIC03940.1), whiE pigment (Orf III, CAA39408.1), colabomycin E (ColC4, AIL50166.1), aryl polyene (ApeO, 6QSP_A), youssoufene (YsfB, URG41680.1) and jadomycin (JadA, AAB36562.1). The conserved CHH motif was indicated by red star (
). Four residues (that is, Phe136, Ala137, Pro235 and Leu362) that were unique to SidF were indicated by red triangle (
).