Fig. 1: Hydroamination and hydration of alkenes.
From: Iron-catalysed radical Markovnikov hydroamidation of complex alkenes
a, Hydroamination of terminal alkenes using transition-metal catalysis or radical methods provides either the Markovnikov or the anti-Markovnikov product. b, Mukaiyama-type hydration with O2 as the radical trapping reagent and improved variant that uses a nitroarene as the C-radical oxygenation reagent, exemplified by the hydration of a complex natural product, aromadendrene. c, The design of a radical amination reagent based on the structure of the successful nitroarene oxygen atom donor. r.t., room temperature; Fe(acac)3, iron acetylacetonate.
