Fig. 5: Scale-up synthesis, 15N-labelling, mechanistic studies and proposed mechanism.
From: Iron-catalysed radical Markovnikov hydroamidation of complex alkenes
a, Larger-scale experiments using reagent 2o. b, The 15N-labelled hydroamidation reagent 15N-2o is readily prepared from commercial Na15NO2. This reagent can be used for the synthesis of complex 15N-marked amine derivatives. c, A 5-exo-cyclization experiment showing the radical nature of the process. d, Analysis of the remainder of reagent 2o after a successful hydroamidation under optimized conditions. e, The proposed mechanism for the Fe-catalysed alkene hydroamidation.
