Extended Data Fig. 6: Crystal structures of SacM in complex with substrate analogue 3 and 6b. | Nature Synthesis

Extended Data Fig. 6: Crystal structures of SacM in complex with substrate analogue 3 and 6b.

From: Structural and mechanistic insights into iminium-catalysed macrocyclization by nuclear transport factor 2-like enzymes

Extended Data Fig. 6: Crystal structures of SacM in complex with substrate analogue 3 and 6b.The alternative text for this image may have been generated using AI.

a, Close-up active site view of SacM-3. Compound 3 and the surrounding residues within 4 Å are shown in cyan and wheat, respectively. The polder (omit) electron density map of 3 (contoured at 3.0 σ) is displayed in grey mesh. b, Close-up view of the active site in SacM-6b. Compound 6b and the surrounding residues within 4 Å are shown in light pink and wheat, respectively. The polder (omit) electron density map of 6b (contoured at 3.0 σ) is shown in grey mesh. Compounds 3 and 6b are coloured as cyan and light pink, respectively, while SacM is shown in wheat.

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