Fig. 2: Substrate scope of the 6-N-BCHep synthesis. | Nature Synthesis

Fig. 2: Substrate scope of the 6-N-BCHep synthesis.

From: Breaking the ‘rule-of-five’ to access bridged bicyclic heteroaromatic bioisosteres

Fig. 2: Substrate scope of the 6-N-BCHep synthesis.The alternative text for this image may have been generated using AI.

Reactions were performed with a mixture of E/Z oximes (or hydrazones) as the substrates, using 1 mol% [Ir(dF[CF3]ppy)2(dtbbpy)]PF6 in MeCN (0.1 M) under blue LED (427 nm) irradiation for 1–4 h. Yields are of isolated products. aThe reaction time is 20 h. b0.5 mol% [Ir(dF[CF3]ppy)2(dtbbpy)]PF6 was used. cThioxanthone (10 mol%) was used as the photocatalyst under 390-nm LED irradiation. d5 h reaction time, and 22% of the substrate was recovered. e24 h reaction time, and 41% of the substrate was recovered. fCH2Cl2 (0.1 M) as the solvent, then acylation using Ac2O. gDMSO (0.1 M) as the solvent. i-Pr, iso-propyl; Bn, benzyl; Ac, acetyl; DMSO, dimethyl sulfoxide.

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