Fig. 3: RAE substrate scope: Alkylation of 3-fluoropicolinonitrile (15, 29–45), functionalized drug molecules (46–49). | Nature Synthesis

Fig. 3: RAE substrate scope: Alkylation of 3-fluoropicolinonitrile (15, 29–45), functionalized drug molecules (46–49).

From: Anti-Friedel–Crafts alkylation via electron donor–acceptor photoinitiation

Fig. 3: RAE substrate scope: Alkylation of 3-fluoropicolinonitrile (15, 29–45), functionalized drug molecules (46–49).

Experimental conditions: RAE = 1 equiv., 0.15 mmol; 3-fluoropicolinonitrile (3–5 equiv.): a3 equiv.; b5 equiv. or for late-stage functionalization aromatic acceptor (3 equiv.); DABCO = 0.5 equiv., 75 μmol; Cs2CO3 = 0.05 equiv., 7.5 μmol, DMSO = 1 ml. Boc, tert-butyloxycarbonyl; b.r.s.m., based on recovered starting material. Isolated yields.

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