Extended Data Fig. 4: Single cell dataset metrics.

a, Parameters from single nucleus datasets. Mean values per nucleus: nCount_ATAC, number of ATAC fragments; nFeature_ATAC, number of ATAC peaks with at least one read; nCount_RNA, number of RNA fragments; and nFeature_RNA, number of genes. b, Transcription start site (TSS) aggregation plots for the scATAC multiome datasets showing the expected enrichment of ATAC fragments. c, WNN UMAP of the dataset split by original sample. Each of the KO and control replicates have a high degree of overlap, demonstrating high reproducibility of cell state changes in Tbx5AKO atria.