Extended Data Fig. 9: Motif analysis of control and KO ATAC regions. | Nature Cardiovascular Research

Extended Data Fig. 9: Motif analysis of control and KO ATAC regions.

From: Tbx5 maintains atrial identity in postnatal cardiomyocytes by regulating an atrial-specific enhancer network

Extended Data Fig. 9

a, Aggregation plots for H3K27Ac at control and KO regions. b, Heatmaps of the H3K27Ac signal at control and KO peaks. c, Top-enriched motifs identified in control regions. The TBOX motif was the most enriched, followed by MEF2. An extended table of non-redundant motifs showing the top 21 most enriched motifs in control regions. d, Transcription factor footprinting analysis demonstrates footprints at TBOX and MEF2 motifs in control clusters (Myocyte_1 and Myocyte_4) compared to KO clusters (Myocyte_5 and Myocyte_6). e, Top-enriched motifs identified in KO regions and extended table of the top non-redundant motifs. f. Occupancy of control and KO ATAC regions by cardiac TFs in aCMs. Occupancy data is from GEO GSE2150653.

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