Fig. 5: Identification of unique and potentially pathogenic autoantibody populations in Myo+SD+ patient serum. | Nature Cardiovascular Research

Fig. 5: Identification of unique and potentially pathogenic autoantibody populations in Myo+SD+ patient serum.

From: An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury

Fig. 5: Identification of unique and potentially pathogenic autoantibody populations in Myo+SD+ patient serum.The alternative text for this image may have been generated using AI.

a, PCA plot of differential antigen targets. b, Venn diagram describing the number of antigen targets in each SLE patient subgroup and their overlap. c, Venn diagrams describing the number of cardiomyocytes and cardiac fibroblast-specific surface proteins and their overlap, representing shared surface proteins. d, Heatmap of potential Myo+SD+ pathogenic autoantibodies targeting cardiac cell surface antigens. e, Linear correlation between patient EF and corresponding read counts of LMO7. P value and r2 were calculated by two-tailed Pearson’s correlation analysis. Ctrl, control; PC, principal component.

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