Extended Data Fig. 2: Allograft inflammatory factor 1 (Aif1) worsens cardiac repair after myocardial infarction (MI).
A Mice with whole body deletion of Aif1 (Aif1-/-) or controls (Aif1 + /+) were subjected to permanent occlusion MI. Percent infarct (INF)/left ventricle (LV), percent area-at-risk (AAR)/LV, and percent INF/AAR were measured one week after MI (n = 5 Aif1 + /+ and n = 6 Aif1-/-, two-tailed unpaired t test, pooled from two independent experiments). B Gene expression in whole cardiac extracts from Aif1 + /+ or Aif1-/- bone marrow chimera mice (n = 3 naïve and n = 5 day 3 MI, two-way ANOVA with Tukey’s test, pooled from two independent experiments). Data are presented as mean ± SEM.
