Extended Data Fig. 8: IL-1β injection increases arrhythmia susceptibility through activation of IL-1R. | Nature Cardiovascular Research

Extended Data Fig. 8: IL-1β injection increases arrhythmia susceptibility through activation of IL-1R.

From: IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression

Extended Data Fig. 8

a, graphical scheme of experiments. IL-1r-/- mice were treated for 15 days with saline or IL-1β subcutaneously (SC). b, representative EKG traces from saline and IL-1β treated mice. c, EKG parameters analyzed: RR interval, p wave duration, and PR interval. d, representative action potential traces from saline and IL-1β treated mice. e, action potential duration (APD) at 30%, 50%, 70% and 90% of repolarization, from saline and IL-1β treated mice. Lower inset panel show adjusted mean ± 95% C.I.All the central lines in the box plots represent the median, the box limits represent the first and third quartiles and the whiskers denote the minimum and maximum values. Categorical data are presented as bar plots (f). P values were calculated with unpaired Student’s t-test (two-tailed) (c), hierarchical analysis with mixed effect model (e), and Fisher’s exact test (two-tailed) (f).

Source data

Back to article page