Fig. 4: Chromatin accessibility changes across time in the brain endothelium. | Nature Cardiovascular Research

Fig. 4: Chromatin accessibility changes across time in the brain endothelium.

From: Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse

Fig. 4

a, Differential chromatin accessibility determined by ATAC-seq within the brain and retinal endothelium (6,540 peaks) of E12.5, P6 and adult mice. b, Top biological processes from GREAT analysis across differentially accessible peaks at each timepoint. c, Top 20 transcription factors ranked by expression for each age. The log2 expression over input is indicated in the y axis. The motif enrichment P value is shown according to the size of the bubble (one-tailed Fisher’s exact test). d, Normalized gene expression in either E12.5, P6 or adult brain and retina endothelium (top) and genomic tracks for endothelial and input brain samples for genes upregulated in E12.5 (Adm), P6 (Tnc) or adult (Slc9a2). Unique peaks to those timepoints are indicated by the transparent vertical gray bar, and DNA binding sites of the top 20 transcription factor motifs that are present in such peaks are indicated below. avg, average.

Back to article page