Extended Data Fig. 1: Maternal WD exacerbates atherosclerosis in offspring Ldlr-/- mice.
a, Representative ultrasound images of LCA from mice were obtained on day 0 and 14 after surgery. They revealed that partial ligation induced flow reversal in LCA during diastole. b, c, IPGTT of female (b; n = 9) and male (c; n = 8) mice in each group at 8 weeks of age. d, e, Plasma levels of TG, CHO, LDL-c, and HDL-c in female (d) and male (e) mice at 8-week-old. n = 6. f, g, Plasma levels of female (f) and male (g) mice at 11-week-old. n = 6. h, IPGTT of female mice in each group at 16 weeks of age. n = 9. i, Plasma levels of female mice at 16-week-old. n = 9. j, IPGTT of male mice in each group at 16 weeks of age. n = 8. k, Plasma levels of male mice at 16-week-old. n = 9 vs. 8. Data are presented as the mean ± SEM. An unpaired two-tailed Student’s t-test was used to determine statistical significance.
