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Atherogenesis

27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring

Nature Cardiovascular Research volume 4, pages 350–352 (2025)Cite this article

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Maternal hypercholesterolemia can exaggerate the development of atherosclerosis in adult offspring. Research now shows that the cholesterol metabolite 27-hydroxycholesterol invokes AP-1-mediated immune memory in progeny endothelial cells to increase vascular inflammation and atherosclerosis severity in adulthood.

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Fig. 1: 27-HC, immune memory and atherosclerosis after maternal hypercholesterolemia.

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Authors and Affiliations

  1. Department of Pediatrics, Center for Pulmonary and Vascular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Chieko Mineo & Philip W. Shaul

  2. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Chieko Mineo

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  1. Chieko Mineo
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  2. Philip W. Shaul
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Correspondence to Philip W. Shaul.

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Mineo, C., Shaul, P.W. 27-hydroxycholesterol and endothelial cell immune memory link maternal hypercholesterolemia with atherosclerosis in the offspring. Nat Cardiovasc Res 4, 350–352 (2025). https://doi.org/10.1038/s44161-025-00631-3

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