Extended Data Fig. 1: A murine model of septic cardiomyopathy.
(a) Left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) of C57BL/6 J mice 6 h post-LPS administration (n = 3, each group). (b) Echocardiographic images of the left ventricle of C57BL/6 J mice 24 h post-LPS administration. (c) Left ventricular ejection fraction (LVEF), LVESD, and LVEDD of C57BL/6 J mice 24 h post-LPS administration (n = 3 in the control [Ctrl] group and n = 4 in the LPS group). (d) Hif1a gene expression in the myocardium of C57BL/6 J mice 24 h post-LPS administration, treated with LPS (n = 3 in the Ctrl group and n = 5 in the 24 h group). (e) Western blot analysis of HIF-1α expression in the myocardium of C57BL/6 J mice 24 h post-LPS administration and its quantification (n = 6, each group). GAPDH was used as an internal control. Data are presented as the mean ± SEM and analyzed using a two-sided t-test. *P < 0.05, **P < 0.01.
