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Glaucoma

Glaucoma discovery on a chip

Nature Cardiovascular Research volume 4, pages 1038–1039 (2025)Cite this article

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Increased intraocular pressure due to decreased outflow of aqueous humor from the anterior chamber of the eye is a major risk factor for the development of glaucoma, a leading cause of blindness. A new bioengineered device models ocular fluid outflow on a chip to advance discovery in the pathogenesis and treatment of glaucoma.

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Fig. 1: Ocular steroid treatment is associated with an increased risk of glaucoma due to increased IOP.

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Acknowledgements

S.E.Q. and N.K. are supported by the Research to Prevent Blindness/Dr. David L. Epstein Award and by US National Institutes of Health grant R01EY025799, awarded to S.E.Q.

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Authors and Affiliations

  1. Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Naoki Kiyota & Susan E. Quaggin

  2. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Susan E. Quaggin

Authors
  1. Naoki Kiyota
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  2. Susan E. Quaggin
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Corresponding author

Correspondence to Susan E. Quaggin.

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Competing interests

S.E.Q. is a founder of Mannin Research, a consultant for Roche and Genentech, and a member of the board of directors for Abbvie.

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Kiyota, N., Quaggin, S.E. Glaucoma discovery on a chip. Nat Cardiovasc Res 4, 1038–1039 (2025). https://doi.org/10.1038/s44161-025-00694-2

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