Fig. 5: Cellular communication in human skeletal muscle is disrupted in PAD. | Nature Cardiovascular Research

Fig. 5: Cellular communication in human skeletal muscle is disrupted in PAD.

From: Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1+ macrophage activation

Fig. 5

a,b, Circle plots showing the number (a) and weight (b) of inferred interactions between cell types in non-ischemic and PAD (left and middle plots) and bar plots quantifying these parameters (right plots). Color and width of the edges indicate the sender and number or weight of interactions, respectively. c,d, Heatmaps showing increased (red) or decreased (blue) number (c) and weight (d) of inferred interactions in PAD. Labels on the left side indicate the cell type expressing the ligands and bottom labels the cell types receiving them. e, Scatter plots showing the strength of the outgoing (x axis) and incoming (y axis) interactions for each cell type in non-ischemic (left) and PAD (right). Color and size of the dots indicate the cell type and the number of inferred interactions, respectively. f, Bar plots showing the relative information flow for significant communication pathways between non-ischemic and PAD.

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