Extended Data Fig. 6: Effect of variants on rRNA processing, translation, and cell growth.
From: Pathogenetic mechanisms of muscle-specific ribosomes in dilated cardiomyopathy
a, 28S/18S rRNA ratio in D308N cells under various dox concentrations. N = 3 biological replicates. b, same as a for 45S/18S rRNA ratios. c, Polysome fractionation for G27D and R161W, as in Fig. 3e. d, Cell growth defect for G27D and R161W, as in Fig. 3f. N = 3 biological replicates with 2 technical replicates. e, Cell growth defect for D308N and shRPL3 cells under various dox concentration. N = 2 biological replicates with 2 technical replicates. Data are mean ± s.d. ns, not significant; * P < 0.05; ** P < 0.001.; *** P < 0.0001; **** P < 00001.
