Extended Data Fig. 6: Physiological profile of 12 week HFD-fed model of pre-diabetes.
Physiological profile of 12 week HFD-fed model of pre-diabetes A) body weight B) plasma insulin, P = 0.054 C) plasma free fatty acids D) fasting plasma glucose E) intraperitoneal glucose tolerance test (IPGTT) F) PCA plot of cardiac metabolomic profile analysed by LC/MS G) Myocardial inflammatory cell profile assessed by flow cytometry. n = 6/group, male, C57/BL6 mice, age at endpoint 20 weeks. Flow experiment n = 3/group *P < 0.05 ***P < 0.001 ****P < 0.0001 by t -test (two sample compafrison) or two-way ANOVA subject to Tukey multiple comparisons post hoc test (IPGTT). n represents biological replicates (individual animals). Source data provided as a Source Data File.
