Extended Data Fig. 3: Systemic metabolic profile.

A) Plasma biochemical profiling *P < 0.05, ** P < 0.01, ***P < 0.001 by one way ANOVA, n = 6/group. Data mean ± SEM. Metabolomic profile of db/db vs AZD treated B) liver C) muscles. Metabolomic data presented as fold change db/db vs AZD-treated db/db. Liver: Control n = 6, db/db n = 7, AZD n = 7. Skeletal Muscle: Control n = 6, db/db n = 6, AZD n = 5. Metabolite fold change with propagated standard error of mean by t-test, two tailed P < 0.05. n represents biological replicates (individual animals). Source data provided as a Source Data File.