Extended Data Fig. 4: cIAP2−/− reverse chimeric mice exhibit greater post-MI injury.
From: Hematopoietic expression of cIAP2 drives inflammation and heart failure after myocardial infarction
a) Heart and lung weights normalized to tibia length from reverse bone marrow transplanted mice. b) LVESD measurements of reverse bone marrow chimeric mice. a)-b): Controls: N = 4; WT recipient MI: N = 8; cIAP2−/− recipient MI: N = 7. c) Estimation of capillary density by Isolectin B4 staining (green); nuclei (DAPI) – blue; scale bar = 50μM. N = 4 per treatment. Data presented are aggregates from two experiments. d) and e) Flow cytometry and cell quantitation from reverse bone marrow chimeric mice 28 days post-MI. Control operated mice: N = 3; MI-operated mice: N = 5 per group. Data presented are aggregates from two experiments. Error bars denote Mean +/- SD; p values were calculated using one-way ANOVA with Bonferroni’s correction.
