Extended Data Table 2 Performance of multi-view DNNs in disease strata in the UCSF test dataset

From: Multiview deep learning improves detection of major cardiac conditions from echocardiography

Ventricular Abnormality Type

(value (95%CI))

AUC

Sensitivity

Specificity

F1

Abnormal LV Size

(>86 ml/m2 for males, >70 ml/m2 for females)

(N=4888)

0.965 (0.946–0.983)

0.929 (0.880–0.975)

0.840 (0.831–0.848)

0.170 (0.143–0.198)

Abnormal LV Function

(LVEF <50%)

(N=5692)

0.949 (0.943–0.955)

0.901 (0.885–0.918)

0.840 (0.831–0.848)

0.652 (0.633–0.67)

Abnormal RV Size

(≥moderately enlarged)

(N=5262)

0.903 (0.890–0.915)

0.806 (0.774–0.837)

0.840 (0.831–0.849)

0.463 (0.438–0.489)

Abnormal RV Function

(≥moderately decreased)

(N=5125)

0.950 (0.939–0.959)

0.891 (0.861–0.92)

0.840 (0.831–0.849)

0.417 (0.389–0.441)

Diastolic Dysfunction by grade

(value (95%CI))

AUC

Sensitivity

Specificity

F1

Grade 1–2

(N=1765)

0.836 (0.821–0.853)

0.734 (0.71–0.756)

0.777 (0.751–0.805)

0.784 (0.767–0.8)

Grade 3

(N=1022)

0.836 (0.817–0.856)

0.736 (0.696–0.776)

0.777 (0.753–0.804)

0.677 (0.644–0.708)

Grade 4

(N=1088)

0.843 (0.824–0.862)

0.742 (0.707–0.778)

0.777 (0.751–0.803)

0.704 (0.674–0.732)

Regurgitation by valve

(value (95%CI))

AUC

Sensitivity

Specificity

F1

Aortic Valve

(N=3719)

0.891 (0.863–0.918)

0.769 (0.677–0.855)

0.829 (0.818–0.839)

0.135 (0.106–0.162)

Mitral Valve

(N=3882)

0.943 (0.932–0.953)

0.904 (0.868–0.933)

0.829 (0.819–0.839)

0.389 (0.361–0.423)

Tricuspid Valve

(N=3916)

0.885 (0.868–0.902)

0.790 (0.747–0.831)

0.829 (0.819–0.839)

0.378 (0.346–0.408)

  1. (DNN) Deep Neural Network, (LV) Left ventricle, (RV) Right ventricle, (AUC) Area under the receiver operating characteristic curve, (CI) Confidence Interval. All values are point estimate (95% confidence interval, derived via bootstrap).