Extended Data Fig. 3: Mediation analysis of proteins on CMR-BMR trait interactions.
From: Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease
a–b. Diagram of mediation models with (a) and without (b) the mediator. The total effect (path c) is the impact of the independent MRI trait on the dependent MRI trait; the direct effect (c’) remains after adjusting for the mediator; and the indirect effect (path a × path b) is mediated through the protein. c–d. Plasma proteins that significantly mediate interactions from CMR to BMR traits (c) or from BMR to CMR traits (d). ISOVF, isotropic volume fraction; FA, fractional anisotropy; MD, mean diffusivity.
