Extended Data Fig. 1: Univariate correlation between CMR and BMR traits.
From: Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease
a. Manhattan plot of two-sided Pearson correlations between 82 CMR and 2,222 BMR traits. The x-axis shows BMR trait categories, and the y-axis shows -log10(P) value and correlation coefficients. The red line denotes the Bonferroni-corrected threshold (P < 2.74×10−7). Gray points represent negative correlations. b. Significant correlations between CMR and BMR trait categories after Bonferroni correction. c. Counts of significant CMR-BMR correlations. WM, white matter; swMRI, susceptibility-weighted MRI; DTI, diffusion tensor imaging; NODDI, neurite orientation dispersion and density imaging; dMRI, diffusion-weighted MRI; rfMRI, resting-state functional MRI; LV, left ventricle; LA, left atrium; RV, right ventricle; RA, right atrium; Asc aorta, ascending aorta; Des aorta, descending aorta; CMR, cardiac MRI; BMR, brain MRI.
