Fig. 2: Assessment of suboptimal, optimal, and excessive cold atmospheric plasma (CAP) doses on non-wounded skin of mice. | Communications Engineering

Fig. 2: Assessment of suboptimal, optimal, and excessive cold atmospheric plasma (CAP) doses on non-wounded skin of mice.

From: Electrochemical sensors for in situ monitoring of reactive species during cold atmospheric plasma-based therapies

Fig. 2

a Experimental setup for in vivo dose definition study. b CAP streamers (pink triangle) during exposure (10 mm diameter electrode) ~1 mm above the skin. c Representative images of CAP-treated areas (60 s, 180 s, and 300 s exposures) in different tested groups over 1 week. Scale bar = 10 mm (dotted circle). Red triangles indicate the grossly visible damage area immediately after CAP treatment (300 s, Day 0) and scar area on days 2, 3, and 7. Exposure location is denoted by white triangles. d Representative H&E-stained histological images of normal tissue skin, CAP-treated (300 s group only) immediately after CAP, and day 1 and day 7 post-treatment. Day 1 shows tissue damage and related inflammation (blue arrows). Day 7 images show completely healed skin with a regenerative epidermis. Yellow arrows denote the epidermis, dermis, muscle, and hair follicles for the normal skin tissue.

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