Fig. 5: Longitudinal profile comparisons in cortical thickness atrophy in BBHI.

a,b, Vertex-wise symmetrized percent change maps of significant clusters surviving family-wise error multiple comparison correction in 533 participants from BBHI, for the primary model (adjusted for age, sex and education; a) and the adjusted model (further adjusted for depression and anxiety symptoms; b). Blue to light blue reflects higher cortical thickness loss for profile 1 in comparison to profile 3 (in a and upper row of b) and profile 2 (lower row of b). In a, final cluster-wise P values are <0.001 for the cluster around the right lateral occipital area, 0.034 for the cluster around the right fusiform area and <0.001 around the left inferior temporal area. In b, when comparing profile 1 versus profile 3, final cluster-wise P values are <0.001 for the cluster around the right lateral occipital area and <0.001 for the cluster around the left inferior temporal area. When comparing profile 1 versus profile 2, the final cluster-wise P value is 0.004 for the cluster around the left inferior temporal area. All analyses were performed with vertex-wise one-factor/two-level general linear models, as provided by FreeSurfer.