Fig. 2: Manhattan and QQ plots for each of the ten MTAG-PHQ-9 GWAS meta-analyses.

The red lines on the Manhattan plots indicate genome-wide significance (P ≤ 5 × 10−8) and the blue lines suggestive significance (P ≤ 1 × 10−5). No further study-wide multiple testing correction was applied. The P-value estimates are derived from a linear regression model with a two-sided test. The FUMA-identified nearest gene to the top variant at each locus is labeled.