Fig. 3: Pooled HRs between 1-MET increase in CRF and the risk of mental and neurocognitive disorders.
Results from two-sided random-effects meta-analyses of prospective cohort studies are shown categorized into depression23,24,25,28,29,37 and all-cause dementia20,21,27,36,38. Individual squares represent study-specific HRs, with horizontal lines indicating 95% CIs. Diamond symbols denote pooled HRs from random-effects models, and red horizontal bars indicate 95% prediction intervals. Point estimates represent HRs. HR values < 1 indicate a lower risk associated with higher CRF. Statistical inference is two-sided and based on 95% CIs, with no adjustments for multiple comparisons. Abbreviations as in Fig. 2.
