Table 4 The potential diagnostic and prognostic miRNA biomarker
Disease/ condition | Species | Source | miRNA | Ref. |
|---|---|---|---|---|
High fat diet effect on DSS-induced colitis | Mice | Visceral adipose tissue-exosomes | ↑miR-155 | |
IBS patients | Human | Serum-exosomes | ↑miR-148b-5p | |
Celiac disease | Human | Serum | ↑miR-192-5p, miR215-5p and miR-125b-5p | |
IBD patients (CD) | Human | Blood | ↑miR-101, and miR-375 ↓miR-21, miR-31, miR-146a, and miR-155 | |
Colon | ↑miR-31, miR-101, and miR-146a ↓miR-375 | |||
Saliva | ↑miR-101 | |||
IBD patients (UC) | Human | Blood | ↑miR-19a, miR-101, miR-142-5p, miR-223, miR-375, and miR-494 ↓miR-21, miR-31, and miR-146a | |
Colon | ↑miR-19a, miR-21, miR-31, and miR-101 | |||
Saliva | ↑miR-21, miR-31, and miR-142-3p ↓miR-142-5p | |||
IBD patients | Human | Colon | ↑miR-21-3p, miR-146a-3p, and miR-155-5p | |
Differentiate Crohn’s colitis from ulcerative colitis | Human | Plasma | ↑miR-598, and miR-642 | |
IBD patients (both CD and UC) | Human | Serum | ↑miR-146b-5p | |
IBD patients | Human | Feces (no differences in serum) | ↑miR-223 and miR-1246 | |
IBD patients | Human | Serum | ↑miR-16, miR-21, and miR-223 | |
Feces | ↑miR-155 and miR-223 | |||
IBD patients-Crohn’s ileitis | Human | Ileum | ↑miR-16, miR-21, miR-223, and miR-594 | |
IBD patients-Crohn’s colitis | Colon | ↑miR-23b, miR-106, and miR-191 ↓miR-19b, and miR-629 | ||
Stricture in CD patients | Human | Mucosa | ↓miR-29b | |
IBD patients (CD) | Human | Feces | ↑miR-15a-5p, miR-16-5p, miR-128-3p, miR-142-5p, miR-24-3p, miR-27a-3p, miR-223-3p, miR-223-5p, and miR-3074-5p ↓miR-10a-5p, miR-10b-5p, miR-141-3p, miR-192-5p, miR-200a-3p, miR-375, miR-378a-3p, and let-7g-5p | |
Active UC | Human | Colon mucosa | ↑miR-20b, miR-98, miR-125b-1, and let-7e | |
UC | Human | Colon | ↑miR-21 and miR-126 | |
Gastrointestinal cancer versus Chronic inflammatory enteropathy | Dog | Feces | ↑miR-451, miR-223, and miR-27a | |
Serum | ↑miR-20b, miR-148a-3p, and miR-652 | |||
Non-inflamed colonic biopsies of CD versus UC | Human | Colon mucosa | ↑miR-196b, miR-199a-3p, miR-199b-5p, miR-320a, miR-150, and miR-223 | |
IBD patients (CD)-Fibrosis | Human | Colon | ↓miR-141, miR-200a, miR-200b, miR-200c, and miR-429 | |
IBD patients (UC)-Fibrosis | ↓miR-141, miR-200b, and miR-429 | |||
Active CD vs. UC patients | Human | Blood | ↑miR-28-5p, miR-103-2, miR-149, miR-151-5p, miR-340, miR-532-3p, and miR-plus-E1153 | |
IBD patients (CD) | Human | Blood | ↑MiR-16, miR-23a, miR-29a, miR-106a, miR-107, miR-126, miR-191, miR-199a-5p, miR200c, miR-362-3p and miR-532-3p | |
IBD patients (UC) | ↑miR-16, miR-21, miR-28-5p, miR-151-5p, miR-155 and miR-199a-5p | |||
IBD patients (both UC and CD) | Human | Serum | ↑miR-127-3p, miR-491-5p, miR-18a, miR-145, miR-185, and miR-29c ↓miR-135a | |
IBD patients (both UC and CD) and remission | Human | Blood | ↑miR-320a | |
IBD patients (both UC and CD) | Human | Feces | ↑miR-16-5p ( ↑ miR-21-5p only in UC) | |
IBD patients (CD) | Human | Serum | ↑miR-144-3p | |
Cecal ligation and puncture sepsis | Mice | Whole blood and serum | ↑miR-16, miR-17, miR-20a, miR-20b, miR-26a, miR-26b, miR-106a, miR-106b, miR-195, and miR-451 | |
IBS patients | Human | Whole blood | ↑miR-150 and miR-342-3p |
