Cancer Metabolism 2.0

The field of cancer metabolism research is entering its 2nd century since the first description of the changes in metabolism of cancer cells by Otto Warburg and his colleague Seigo Minami in 1923. 100 years on, only a few discoveries have been translated into clinical practice. The field has seen progress in understanding the metabolic interplay between cancer cells and their microenvironment, in different organs and in the systemic context, revealing tissue dependencies and metabolic flexibility, appreciating the role of metabolic alterations as drivers of tumour initiation and metastatic progression. Integrating dietary interventions, along with targeting and monitoring approaches based on tumour metabolism into existing cancer therapy shows great promise for enhancing treatment efficacy and patient outcomes. This collection of clinical, translational and preclinical studies as well as review and opinion articles from across Springer Nature journals highlights the breadth of metabolism research in the cancer setting and its potential for improving cancer care.