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In this Review, Xia et al. discuss the potential of colchicine as a therapy for atherosclerotic cardiovascular disease, highlighting evidence from clinical trials and mechanistic studies showing its effects on vascular inflammation, plaque stability, and immune and vascular cell function. They also emphasize that mixed results in recent cardiovascular and cerebrovascular trials highlight the need to integrate mechanistic insights with clinical evidence to refine colchicine use and guide precision anti-inflammatory strategies.
Zhou et al. review recent technological advances in mRNA-based biotechnologies for cardiovascular disease, examining preclinical applications, clinical trial outcomes, and the key challenges and future directions of these approaches.
Yeow et al. review the pathogenesis of rheumatic heart disease, discuss the role of valve biology in the progression of the disease, highlight ongoing research to address the critical healthcare burden and describe recent advances into the underlying pathogenic mechanisms.
