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Liu, Neve et al. use large-scale loss-of-function RNA-interference screens to identify circular RNAs that are direct regulators of important signalling pathways and also common essential and tissue-specific circRNAs.
In two independent studies, Sun, Liu et al. and Sun et al. develop SPATAC-seq to map the chromatin accessibility landscape of zebrafish embryogenesis and mouse organogenesis, respectively, and identify transcription regulators that determine cell fate.
In two independent studies, Sun, Liu et al. and Sun et al. develop SPATAC-seq to map the chromatin accessibility landscape of zebrafish embryogenesis and mouse organogenesis, respectively, and identify transcription regulators that determine cell fate.
Chidley et al. report a CRISPR interference/activation screening platform to systematically interrogate the contribution of nutrient transporters to support cancer cell proliferation in environments of variable composition.
Morgan, Pernes and colleagues perform mass spectrometry-based targeted lipidomics and provide a comprehensive lipid profile of human and mouse immune cells, which they then show confer differential ferroptosis susceptibilities.
Roider, Baertsch et al. present a spatially resolved resource map of the T cell infiltration landscape across and within patients with distinct B cell non-Hodgkin lymphoma entities.
Zwick et al. examine longitudinal transcriptional patterns across the entire mouse and human small intestine and find that, in both species, the small intestine comprises five domains of nutrient absorption and three regional stem cell populations.
Using low-input lipidomics in mouse and human embryos, Zhang, Shui, Li and colleagues find that lipid unsaturation increases with development towards the blastocyst stage. They further show that lipid desaturases contribute to successful embryo implantation.
Lin Li, Lei Li et al. perform single-cell multi-omics to study the transcriptome, the DNA methylome and chromatin accessibility in human arrested embryos and find that cytoskeletal defects cause embryonic arrest characterized by zygotic genome activation.
