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The composition of extracellular vesicles (EVs) is central to their function, yet the field lacks systematic characterization. Here Rai et al. perform proteomic and lipidomic analyses of circulating human plasma EVs and create a web tool for data exploration.
Li, Li, Wu et al. use a proteomics approach, PhastID to identify protein components of nuclear condensates (NCs). They reveal crosstalk between NCs, the dynamics of condensate components and identify an NC formed by BUD13.
Xu, Kong, Li, Pisignano and colleagues provide a map of pseudouridine sites in human noncoding RNA. Using a systematic knockout approach, they associate each pseudouridine site with the activity of a specific pseudouridine synthase.
Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline and showing that supplementation enhances stemness.
Hu et al. use single-cell RNA sequencing to explore the transcriptional profile of human amnion samples spanning the developmental window from Carnegie stage (CS)16 to CS23.
Petropoulos and colleagues perform single-cell transcriptomics, spatial, functional and comparative analyses, and show that the guinea pig presents high similarity with early human embryogenesis.
