Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This Review presents an updated view on telomeric chromatin as a dynamic structure with a specialized histone organization and discusses the mechanisms of its regulation by cis-acting subtelomeric elements, as well as their relevance in disease.
Rizzotto et al. discuss the causes and consequences of deregulated mitosis that allow cells arrested in mitosis to escape to the next interphase, where they can initiate inflammatory signalling or undergo cell death, with therapeutic implications.
