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    iCOGS collection provides a collaborative model

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    Gene silencing through RNA interference (RNAi) has become the tool of choice for genome-scale, high-throughput analyses of gene function and has had a tremendous impact on science and drug discovery. Now, RNAi libraries targeting whole genomes or functionally related pathways permit systematic screens for clinically relevant components of cellular networks. Advances in rational design, sequence selection strategies and delivery options have substantially improved the utility of short interfering RNA (siRNA), short hairpin RNA (shRNA) and microRNA (miRNA) tools for screening.

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    MicroRNAs (miRNAs) — an abundant class of small non–protein–coding regulators of gene expression — play an important role in tumorigenesis and, depending on their targets, can function as tumour suppressors or oncogenes. Crucially, miRNA–expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment.

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    The sequencing of the equivalent of an entire human genome for $1,000 has been announced as a goal for the genetics community, and new technologies suggest that reaching this goal is a matter of when, rather than if. What then? In celebration of its upcoming 15th anniversary, Nature Geneticsasked prominent geneticists to weigh in on this question: what would you do if this sequencing capacity were available immediately?

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