Review Articles in 2022

Godbout and colleagues discuss the neuroimmune mechanisms that underlie social-stress defeat, anxiety, and post-traumatic stress disorder.

The explosion of single-cell and systems approaches in immunology risks leaving the uninitiated behind. This guide to systems immunology is designed for immunologists who want an introduction to the area.

Boussiotis and colleagues review the hallmarks of tumor-associated macrophages and discuss the mechanisms that contribute to their pathophysiological adaptations to the tumor microenvironment.

Yu et al. review the roles played by follicular helper T cells in sustaining germinal center B cell responses and vaccination strategies, as well as potential pathogenic autoimmune responses.

Qi et al. provide an in-depth analysis of antibody responses generated in response to SARS-CoV-2.

Zehn and colleagues review the cellular fates and precursor trajectories that allow antigen-specific CD8⁺ T cells to persist in the face of chronic infection and cancer.

Satpathy and colleagues review the epigenetic underpinnings that result in T cell exhaustion.

The transcription factor TCF-1 has multiple roles during T cell development and in mature T cells. Gounari and Khazaie review the potential mechanisms by which TCF-1 regulates gene expression.

Enormous progress has been made in the ten years since immune checkpoint blockade (ICB) was first approved for treating melanoma. Zappasodi and Huang review the current state of the art of ICB for melanoma and prospects for the future.

Gabrielle Belz and colleagues review the influence that innate lymphoid cells have on cancer immune responses.

Immunogenic cell death (ICD) is central to both homeostatic and pathophysiological events. Kroemer et al. review the mechanisms of ICD and its role in therapy and disease.

Kanneganti and Diamond review the key role played by innate immunity in the control and immunopathology of COVID-19.

Paul Moss reviews the current knowledge of T cell immunity in the control of SARS-CoV-2.

It is increasingly obvious that individuals are experiencing post-COVID-19 syndromes, or ‘long-haul COVID’. Here, Merad and Mehandru eview currently available knowledge of the underlying pathophysiological mechanisms of these sequelae, elaborating on persistent inflammation, induced autoimmunity and putative viral reservoirs.

Children are generally resistant to severe disease resulting from SARS-CoV-2 infection, but cases of pediatric COVID-19 and a new syndrome called MIS-C can occur. In this Review, the authors summarize what is known about the immunology of COVID-19 and MIS-C and how the pediatric response to SARS-CoV-2 is different from the immune response in adults.