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The current definition of myocardial infarction is applied inconsistently, with implications for patients and research; here, the authors propose a new definition and call for further research and consensus.
The recently completed NCI-MATCH is one of the largest precision oncology trials undertaken to date; this Perspective discusses key aspects of its design and conduct, and lessons for future precision oncology studies.
The health sector must play its part in decarbonization efforts; this Perspective outlines the principles of fair pathways to net-zero healthcare that are attentive to health and socioeconomic inequalities.
This Perspective outlines practical considerations for designing and testing visual displays to communicate health information, using illustrative case examples.
The authors describe a localized toxicity syndrome that is associated with immunotherapy treatment for CNS tumors and propose a new grading scale—with the goal of promoting research and standardizing both reporting and management.
Moving away from the traditional ‘tumor-centric’ view, the authors explore how systemic biology, as well as aging, co-morbidities and co-medications, all interact and influence cancer development and progression.
Technological advances are transforming evidence generation in medicine; for these advances to impact public health, the clinical trial landscape must evolve and adapt to keep pace.
