Journal Clubs

A preprint by El-Daher et al. describes an interferonopathy-associated mutation in the chromatin remodeller ATRX, which identifies an unexpected role for nuclear cGAS in transcriptional regulation.

A preprint by Villazala-Merino et al. shows that allergen-specific memory B cells must re-enter germinal centres to differentiate into IgE-producing plasma cells, which occurs in lymph nodes but not at barrier sites.

A preprint by Zhu et al. shows that protease allergens induce neural hypersensitivity by activating mTORC1 signalling in sensory neurons.

A preprint by McCarron et al. investigates immunodominance hierarchies in response to cancer vaccines targeting neoantigens.

A preprint by Boulat et al. reports that tumour-derived lactate blocks B cell migration from cancer-associated lymph nodes, preventing the formation of tertiary lymphoid structures in the tumour.

A preprint by Breuer et al. reports that type I IFN signalling in tumour cells promotes lymph node metastasis but suppresses metastasis to distant organs such as lung.

A preprint by Liu et al. shows proof-of-concept for a treatment for autoimmune diseases such as SLE using synthetic immune receptor T cells that target 9G4 idiotope B cells.

A preprint by Bockman et al. reports a cDC2-CD4⁺ T cell axis that mediates local tumour control after ablation of intratumoral T_reg cells, without eliciting autoimmunity.

A preprint by Zhijie et al. identifies somatic mutations in TYK2 that are enriched in tumour-infiltrating lymphocytes and associated with an increased antitumour response.

A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.

A preprint by Srinivasan et al. describes the role of the gut microbiota and serum amyloid A in regulating retinoid flux that is important for myeloid cell migration and T cell priming.

A preprint by Rivera et al. explores how retroelement expression establishes a tolerogenic environment towards food antigens in the gut, shedding new insights into the immune regulatory role of retroelements.

A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.

A recent preprint by Floyd et al. presents the most comprehensive mapping to date of the human lymphocyte ‘surfaceome’.

A preprint by Wu et al. identifies BRD4 as a sensor of pH, with notable implications for the regulation of inflammatory genes.

A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.

A preprint by Han et al. reports that tumour cells acquire iron in the bone marrow through phenotypic mimicry of erythroblasts, which promotes metastasis and leads to systemic anaemia.

A preprint by Srivastava et al. reports that C19S modification of insulin, which occurs in response to a stressed microenvironment, promotes pro-inflammatory T cell activation and memory responses.

A preprint by Li et al. presents a comprehensive pan-cancer atlas of tumour-specific peptides that markedly expands the known tumour antigen repertoire.

A preprint by Cortez et al. explores how IL-25 produced in response to helminth infection in mice rewires intestinal ILC2s to retain a 'memory' of prior infection.