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Oncogene (79)
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Showing 1–50 of 228 results

Advanced filters: Author: A. Alessi Clear advanced filters

Intestinal macrophages modulate synucleinopathy along the gut–brain axis

Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understanding the accompanying mechanisms could pave the way for early-stage biomarkers.

Sebastiaan De Schepper
Viktoras Konstantellos
Tim Bartels
ResearchOpen Access28 Jan 2026
Nature

P: 1-11
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

Clare A Hall-Jackson
Michel Goedert
Philip Cohen
Research08 Apr 1999
Oncogene

Volume: 18, P: 2047-2054
Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism

R Meili
P Cron
K Ballmer-Hofer
Research03 Mar 1998
Oncogene

Volume: 16, P: 903-907
Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos

Yair N Doza
Clare A Hall-Jackson
Philip Cohen
Research14 Jul 1998
Oncogene

Volume: 17, P: 19-24
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)

Saori Sato
Naoya Fujita
Takashi Tsuruo
Research08 Mar 2002
Oncogene

Volume: 21, P: 1727-1738
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A. E. Cross
Dario R. Alessi
Brian A. Hemmings
Research28 Dec 1995
Nature

Volume: 378, P: 785-789
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human

Deciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and show dynamic vascular-to-astrocyte signaling relevant to human neuropathology.

Steven A. Hill
Isabel Bravo-Ferrer
Blanca Díaz Castro
ResearchOpen Access06 Nov 2025
Nature Communications

Volume: 16, P: 1-24
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

Lindsey A. Allan
Nick Morrice
Paul R. Clarke
Research09 Jun 2003
Nature Cell Biology

Volume: 5, P: 647-654
RAB family gene expression in breast cancer cells under influence of paclitaxel

Jolanta Rzymowska
Tadeusz Malewski
Andrzej Wilkolaski
ResearchOpen Access10 Aug 2011
Nature Precedings

P: 1
A novel human ERK phosphatase regulates H-ras and v-raf signal transduction

Deug-Yong Shin
Toshio Ishibashi
Donald P Bottaro
Research05 Jun 1997
Oncogene

Volume: 14, P: 2633-2639
Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade

E Lengyel
H Wang
D Boyd
Research29 May 1997
Oncogene

Volume: 14, P: 2563-2573
The role of fibrinolytic factors in ischaemia

M Pandolfi
A Al-Rushood
Research01 Mar 1991
Eye

Volume: 5, P: 159-169
Beyond academia: debunking the industry–academia barrier myth

Some researchers run both academic labs and companies, challenging the idea that the two sectors operate in silos.

Julie Gould
Comments & Opinion09 Feb 2022
Nature
The Dutch city where industry–academia collaborations flourish

Eindhoven University of Technology was set up to partner with local companies. Mutual trust and a respect for academic freedom are key, Julie Gould discovers.

Julie Gould
Comments & Opinion02 Mar 2022
Nature
A rare human variant that disrupts GPR10 signalling causes weight gain in mice

The brain-expressed receptor GPR10 is involved in energy homeostasis in mice. Here the authors identify rare loss of function variants in GPR10 in people with severe obesity and showed that one of these variants causes obesity when modelled in mice, suggesting that future studies could explore GPR10 as a potential target for weight-loss therapy.

Fleur Talbot
Claire H. Feetham
I. Sadaf Farooqi
ResearchOpen Access15 Mar 2023
Nature Communications

Volume: 14, P: 1-10
NUAK2 is a critical YAP target in liver cancer

Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy.

Wei-Chien Yuan
Brian Pepe-Mooney
Fernando D. Camargo
ResearchOpen Access16 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

Danielle K Lynch
Christine A Ellis
Ian D Hiles
Research04 Jan 2000
Oncogene

Volume: 18, P: 8024-8032
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics

Thierry Dubois
Olivia Paléotti
Philippe Chavrier
Research27 Mar 2005
Nature Cell Biology

Volume: 7, P: 353-364
Intercalation and delamination of layered carbides and carbonitrides

Intercalation materials are of interest for batteries because of their capability of accommodating ions in their layered structures. Mashtalir et al. develop a new battery electrode material using two-dimensional intercalated carbides, which exhibit high lithium-ion conductivity and capacity.

Olha Mashtalir
Michael Naguib
Yury Gogotsi
Research16 Apr 2013
Nature Communications

Volume: 4, P: 1-7
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

Robert F. Paulson
Shirly Vesely
Alan Bernstein
Research01 Jul 1996
Nature Genetics

Volume: 13, P: 309-315
Redox-driven photoselective self-assembly

This study presents a strategy to form luminescent gels by chemically reducing non-emissive Pt(IV) complexes to emissive Pt(II). Additionally, UV light can induce Pt(IV) reduction, and the resulting fibers can be selectively elongated with visible light.

Dario Alessi
Luca Morgan
Alessandro Aliprandi
ResearchOpen Access09 May 2025
Nature Communications

Volume: 16, P: 1-11
Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

R Gum
H Wang
D Boyd
Research27 Mar 1997
Oncogene

Volume: 14, P: 1481-1493
Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

Deborah A Altomare
Gary E Lyons
Joseph R Testa
Research26 May 1998
Oncogene

Volume: 16, P: 2407-2411
Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells

Rodney J Fiddes
Peter W Janes
Roger J Daly
Research04 Jun 1998
Oncogene

Volume: 16, P: 2803-2813
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential

Ramon G Manzano
Luis M Montuenga
Michael J Birrer
Research25 Jun 2002
Oncogene

Volume: 21, P: 4435-4447
The phospholipid PI(3,4)P₂ is an apical identity determinant

During de novo establishment of apical-basal polarity, a basolateral membrane must be converted into an apical delivery zone. Here, the authors use MDCK 3D cysts to uncover that the phospholipid PI(3,4)P2 is an apical membrane determinant.

Álvaro Román-Fernández
Julie Roignot
David M. Bryant
ResearchOpen Access28 Nov 2018
Nature Communications

Volume: 9, P: 1-17
Kinase interaction analysis predicts actions of the WNK-OSR1/SPAK pathway

Experimental data-driven kinase interaction predictions expand reach of the WNK-OSR1/SPAK pathway by facilitating the identification of multiple OSR1 and SPAK interaction partners.

Clinton A. Taylor IV
Ji-Ung Jung
Melanie H. Cobb
ResearchOpen Access05 Sept 2025
Communications Biology

Volume: 8, P: 1-18
Akt2 interacts with Snail1 in the E-cadherin promoter

P Villagrasa
V M Díaz
A García de Herreros
Research12 Dec 2011
Oncogene

Volume: 31, P: 4022-4033
Increase in both pro-thrombotic and anti-thrombotic factors in obese premenopausal women: relationship with body fat distribution

G De Pergola
V De Mitrio
R Giorgino
Research01 Jul 1997
International Journal of Obesity

Volume: 21, P: 527-535
Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm

Anderson et al. show that LIF, ActA and Wnt support self-renewal in both pluripotent and endodermal cells. Upon removal of insulin, they induce differentiation of naive PSCs into extra-embryonic primitive endoderm and primed PSCs into definitive endoderm.

Kathryn G. V. Anderson
William B. Hamilton
Joshua M. Brickman
Research25 Sept 2017
Nature Cell Biology

Volume: 19, P: 1164-1177
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells

T Mochizuki
S Furuta
T Kamata
Research13 Mar 2006
Oncogene

Volume: 25, P: 3699-3707
Structural evidence for a two-step process in the depinning of the superconducting flux-line lattice

U. Yaron
P. L. Gammel
K. N. Clausen
Research31 Aug 1995
Nature

Volume: 376, P: 753-755
It started with a western

Maria Antonietta (Antonella) De Matteis is a professor of biology at the University of Naples Federico II and leads the cell biology programme at the Telethon Institute of Genetics and Medicine in Pozzuoli, Italy. Antonella recalls the beginning of her research program on phosphatidylinositol 4-phosphate (PI4P) at the Golgi, published in our pages in 1999 and 2004.

Maria Antonietta De Matteis
Comments & Opinion23 Jan 2024
Nature Cell Biology

Volume: 26, P: 174
Evolutionary conservation of components of the protein translocation complex

Enno Hartmann
Thomas Sommer
Tom A. Rapoport
Research17 Feb 1994
Nature

Volume: 367, P: 654-657
Identification of the breast cancer susceptibility gene BRCA2

Richard Wooster
Graham Bignell
Michael R. Stratton
Research28 Dec 1995
Nature

Volume: 378, P: 789-792
Novel pathway of chalcopyrite formation at low temperature in microenvironments of acidic, metal-rich sediments

Chalcopyrite, the main copper ore mineral, is usually formed at high temperatures, according to a study that shows that microbial processes might promote its low-temperature formation in acidic pit lake sediments, with implications for bioremediation and biomining.

Andrey M. Ilin
Iñaki Yusta
Javier Sánchez-España
ResearchOpen Access20 Nov 2025
Communications Earth & Environment

Volume: 6, P: 1-14
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons

C9orf72 ALS/FTD polyGR and polyPR knock-in mice show cortical hyperexcitability and motor neuron loss accompanied by an increase in extracellular matrix proteins in the spinal cord that is conserved in patient iPS cell-derived neurons and is neuroprotective.

Carmelo Milioto
Mireia Carcolé
Adrian M. Isaacs
ResearchOpen Access29 Feb 2024
Nature Neuroscience

Volume: 27, P: 643-655
The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots

Coordinating protein translation with energy supply is a significant challenge faced by cells. Here, the authors found that the protein quality control network may provide a link between the two.

Foozhan Tahmasebinia
Yinglu Tang
Zhihao Wu
ResearchOpen Access25 Jan 2025
Nature Communications

Volume: 16, P: 1-24
PI3K/Akt and apoptosis: size matters

Thomas F Franke
Christoph P Hornik
Chizuru Sugimoto
Reviews08 Dec 2003
Oncogene

Volume: 22, P: 8983-8998
Rictor is a novel target of p70 S6 kinase-1

C Treins
P H Warne
J Downward
Research23 Nov 2009
Oncogene

Volume: 29, P: 1003-1016
Germline variants associated with toxicity to immune checkpoint blockade

A genome-wide association study in large cohorts of patients with different types of cancer treated with immune checkpoint inhibitors identifies genetic variants associated with immune-related adverse events.

Stefan Groha
Sarah Abou Alaiwi
Alexander Gusev
Research16 Dec 2022
Nature Medicine

Volume: 28, P: 2584-2591
Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors

Fusion genes have been proposed as a potential mechanism of resistance to EGFR tyrosine kinase inhibitors (TKIs) in lung cancer. Here, the authors identify gene fusions that are associated with resistance to EGFR TKIs in non-small cell lung cancers, and test how these fusions impact the response to EGFR TKIs in vitro.

Yoshihisa Kobayashi
Geoffrey R. Oxnard
Pasi A. Jänne
ResearchOpen Access24 Sept 2022
Nature Communications

Volume: 13, P: 1-14
Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival

Paul Ferrigno
Pamela A Silver
Research04 Nov 1999
Oncogene

Volume: 18, P: 6129-6134
Repression of cancer cell senescence by PKCι

J A Paget
I J Restall
I A J Lorimer
Research28 Nov 2011
Oncogene

Volume: 31, P: 3584-3596
PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma

C Simon
M J Hicks
D Boyd
ResearchOpen Access11 Jun 1999
British Journal of Cancer

Volume: 80, P: 1412-1419
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression

Variation in the promoter of the gene encoding uromodulin, the most abundant protein in urine, affects the individual risk of developing hypertension or chronic kidney disease. Luca Rampoldi, Olivier Devuyst and their colleagues show that the uromodulin risk alleles are associated with higher levels of uromodulin expression. This can promote hypertension, by stimulating sodium reabsorption by the loop of Henle in the kidney, and kidney damage in both mice and humans.

Matteo Trudu
Sylvie Janas
Luca Rampoldi
Research03 Nov 2013
Nature Medicine

Volume: 19, P: 1655-1660
Milestone in predicting core plasma turbulence: successful multi-channel validation of the gyrokinetic code GENE

Plasma turbulence is the main driver to deteriorate the performance of fusion power plants. This work presents an unprecedented comparison of plasma turbulence between experiment and simulation, proving that the gyrokinetic model GENE reached a high level of maturity to predict core turbulence.

Klara Höfler
Tobias Görler
S. Zoletnik
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart

M A C Fauchon
T J Pell
L V Mayne
ResearchOpen Access01 Aug 2005
Experimental & Molecular Medicine

Volume: 37, P: 311-322
PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells

Yong Choi
Jie Zhang
Weiqun Li
Research02 Aug 2002
Oncogene

Volume: 21, P: 5289-5300

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