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In this study, authors investigate what happens to magma before a volcanic eruption. They find that crystals react to magma flow before it reaches the surface, preserving a mechanical fingerprint of the forces driving eruptions.

JWST phase-curve observations reveal that the two innermost TRAPPIST-1 planets emit thermal radiation consistent with bare rocky surfaces, indicating that both lack thick atmospheres.

In this study, the authors identify inhibitory brainstem neurons that innervate the entire spinal cord as parts of a descending pain-inhibits-pain circuit. Their activation causes body-wide analgesia, while silencing induces pain in response to innocuous stimuli.

National parochialism is the tendency to cooperate more with people of the same nation. In a 42-nations study, the authors show that national parochialism is a pervasive phenomenon, present to a similar degree across all the studied nations, and occurs both when decisions are private or public.

Cell-permeable nanobodies overcome a major barrier to intracellular protein targeting. Franz, Rubil and colleagues show that delivery of a CFTR-binding nanobody into airway epithelial cells from patients with cystic fibrosis homozygous for the F508del-CFTR mutation stabilizes misfolded CFTR chloride channels and synergizes with the clinically approved modulator combination elexacaftor/tezacaftor/ivacaftor to restore CFTR function to near-normal levels.

Schiller and colleagues present a systematic comparison of methods that quantify whether pairs of cell types preferentially co-occur in tissues, highlighting their strengths and limitations. This study also introduces COZI for sensitive detection of directional spatial relationships.

As presented at the 2026 AACR Annual Meeting: in a phase 1b trial, patients with microsatellite-stable colorectal cancer received a FAP-4-1BB ligand together with the CEA-directed T cell engager cibisatamab; the treatment was safe, and biomarker analysis showed induction of immunity in line with the biological rationale.

Modular integration of bacterial strains expands the application range of whole-cell bioelectric sensors.

In vivo adenine base editing corrects a common Pex1 pathogenic allele in mouse models of Zellweger spectrum disorder, rescuing liver pathology, fatty acid levels, body weight and peroxisome function.

An Earth system model estimates that natural halogens, of marine biotic and abiotic origin, remove about 13% of present-day global tropospheric O₃. Projections suggest this ratio is stable through 2100, with high spatial heterogeneity, despite increasing natural halogens.

Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the potential of protecting naturally regenerating secondary forests to reverse biodiversity losses.

Exploiting the differences between quantum and classical physics typically requires nonlinear devices. Quantum nonlinear effects have now been demonstrated in a nanomechanical resonator due to strong coupling with an intrinsic two-level defect.

MsbA mediates the transport of lipopolysaccharide across the inner membrane. Here, the authors show specific MsbA-lipid interactions can tune the selectivity for binding ATP over ADP and present five structures of MsbA with one bound to lipid.

Millisecond pulsar PSR J0435+3233, with a spin-down rate that is 100 times higher than those of other millisecond pulsars, occupies a unique position on the P–Ṗ diagram. This pulsar challenges classical recycling models and constrains spin-up theories.

Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.

Store-operated Ca²⁺ entry is essential for cellular signalling, yet excessive calcium influx drives disease. Here, authors develop genetically encoded CRAC channel inhibitory binders (CRABs) to precisely modulate Ca²⁺ signalling, with therapeutic potential in channelopathies and cancer immunotherapy.

mGWAS reveals ZmICE1 as a key hub for integrating amino acid metabolic pathways and cold tolerance in maize. Natural variation in ZmICE1 promoter regulates the binding affinity of ZmMYB39, which confers the diverse cold tolerance in maize.

Polyamides (PAs) or nylons are types of plastics with wide applications, but due to their accumulation in the environment, strategies for their deconstruction are of interest. Here, the authors screen 40 potential nylon-hydrolyzing enzymes (nylonases) using a mass spectrometry-based approach and identify a thermostabilized N-terminal nucleophile hydrolase as the most promising for further development, as well as crucial targets for progressing PA6 enzymatic depolymerization.

After being internalized by cells, nanoparticles can, in rare events, acquire a biomolecular condensate corona. These complexes can reach the extracellular space, where they can deliver their acquired proteins and RNA content to other cells.

The study reveals a ‘chemocentric’ strategy for identifying charged molecular glue degraders, through discovering a bromodomain-binding molecular glue degrader prodrug that is metabolically activated in cells to recruit the YPEL5-CTLH E3 ligase.

Two individuals with KCNT1-related epileptic encephalopathy were treated with a KCNT1-targeting antisense oligonucleotide, leading to significant reductions in seizure frequency and intensity, but also the development of hydrocephalus.

This case study reports human immunodeficiency virus remission without antiretroviral treatment in an individual who received an allogeneic haematopoietic stem cell transplantation from a sibling donor with a homozygous CCR5Δ32 mutation.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Recombination can speed up adaptation by bringing beneficial alleles together. However, this study shows rapid adaptation in Threespine Stickleback fish depends more on the initial frequency of alleles and mating of key individuals than recombination.

Protein phosphatase 5 (PP5) is highly conserved across eukaryotes. Yan et al. show that de-repression of PP5 by the chaperone organizer HOP1 activates NLR-mediated autoimmunity through dephosphorylation of the protein kinase CRCK3 in Arabidopsis.

A study examines the effects of mutations that occur naturally in T cell cancers, reporting that such mutations can potentially be exploited to increase the potency of T cell therapies.

It is unclear whether the superconducting pairing in moiré graphene is driven primarily by electronic interactions. Now, by tuning the electrostatic environment, the authors show that these interactions may play a crucial role in both mediating the pairing and screening it.

This work introduces HANNA, a strictly consistent machine learning model for predicting phase equilibria and other thermodynamic properties of multi-component mixtures only from the molecular structure.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Starburst galaxies are seen to host galaxy-scale winds, which are super-fast and could be powered entirely by the thermal pressure of gas heated by supernovae.

Growth of wind and solar energy share demonstrates different dynamics between the initial phases of adoption as compared with the advanced stages. Cherp et al. study the growth dynamics of renewable energy and show that laggards may continue to struggle to achieve high growth rates despite learning from early adopters’ experience.

Du and colleagues present SMART, a scalable and computationally efficient framework for integrating spatial multi-omics data to identify tissue domains. The approach shows applicability to large and multi-section spatial profiling datasets.

The microbiomes associated with reef corals are complex and diverse. Here, the authors investigate fire coral clones naturally occurring in distinct habitats as a model system to disentangle the contribution of host genotype and environment on their microbiome, and predict genomic functions based on taxonomic profiles.

Myopathy caused by BAG3 mutation disrupts muscle protein homeostasis and leads to severe muscle weakness. In mouse models, the authors demonstrate that impaired autophagy drives the pathology, while gene therapy targeting the mutated BAG3 improves muscle function.

Appel et al. found that deceptive networks reached over 37 million Facebook and 3 million Instagram users during the 2020 US elections, with the majority of this exposure driven by 3 networks and amplified by ordinary users resharing the content.

Tunable continuous-wave terahertz radiation spanning 1–11 THz is generated at room temperature via difference-frequency generation process in nonlinear metasurfaces. Microwatt-level terahertz output is achieved by pumping the metasurfaces with two milliwatt-level continuous-wave mid-infrared lasers.

Mediterranean ecosystems are at risk of invasive weeds. Here, the authors assess fitness-related traits in common dandelions with culling experiments, finding that plants with intact microbiomes exhibit increased competitiveness in comparison to local species.

Small cell lung cancer (SCLC) cells show inherently low antioxidant defenses, making them prone to lethal oxidative stress induced by thioredoxin reductase 1 (TXNRD1) inhibitors. Here, authors demonstrate that activating NRF2 mediated tissue protection allows increased therapeutic dose of TXNRD1 inhibitors to enhances SCLC cell killing in vivo without added toxicity to healthy tissues.

Fluorochemicals improve our quality of life, but there is an increasing concern over their production and the negative impact on health and the environment. Now chemical recycling of fluorochemicals via base-induced defluorination has been demonstrated, and the resulting potassium fluoride has been used to synthesize organic and inorganic compounds.

BRD2 is key for RNA polymerase II recruitment at promoters, becoming critical in the absence of BRD4 or upon pause-release inhibition. Depletion of MOF or deletion of BRD2’s intrinsically disordered region mimics transcriptional defects caused by BRD2 loss.

This Swedish population-based cohort study identified an association between exposure to assault/victimization and obsessive–compulsive disorder risk, particularly within the first year after exposure.

tRNA deacylases have evolved as resistance genes towards natural products that contain non-canonical amino acids by preventing their mistranslation. Now a strategy has been developed that leverages tRNA deacylases as class-agnostic genomic markers for amino acid-based biosynthetic gene clusters, identifying thousands of cryptic clusters and enabling the discovery of amino acid-based natural products.

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations are of task-relevant locations.

Xiang, Wang, Tian et al. report that during nutrient insufficiency, inflammatory cytokines promote a ZBTB5-mediated mechanism to activate mTORC1 signalling, thereby enhancing amino acid uptake in tumour cells and restricting antitumour immune response.

Recovery of 48 bat and 9 horse HeV genomes from Australia (2016–2020) identified four Hendra virus clades, offering insights into evolutionary dynamics.