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Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Electronic spins in Si are potentially useful in the development of solid-state quantum devices, but its degenerate valley states limits this potential. Zhang et al.use a genetic algorithm to identify a Ge/Si-multilayer-clad Si quantum structure whose valley splitting is increased by an order of magnitude.

Multielectron quantum dots offer a promising platform for high-performance spin qubits; however, previous demonstrations have been limited to single-qubit operation. Here, the authors report a universal gate set and two-qubit Bell state tomography in a high-occupancy double quantum dot in silicon.

Malaria control and elimination require environmentally safe strategies. Here, the authors propose L-DOPA, a naturally occurring tyrosine derivative, as a mosquito dietary intervention that can shorten lifespan and reduce malaria parasite burden of female Anopheles gambiae mosquitoes.

Researcher used carbon dating to provide evidence that humans had arrived in Brazil much earlier than previously thought.

Silicon-based spin qubits are promising candidates for a scalable quantum computer. Here the authors demonstrate the violation of Bell’s inequality in gate-defined quantum dots in silicon, marking a significant advancement that showcases the maturity of this platform.

CD4⁺ T cells promote immunity to tuberculosis infection via macrophages. Here the authors show upregulation of SLAMF1/CD150 on infected macrophages after interaction with CD4⁺ T cells and that the presence of SLAMF1 promotes ROS production by macrophages and the absence of Slamf1 in macrophages results in higher mycobacterial loads in infected mice.

Here, five leading researchers describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms involved and current approaches to the management of affected patients.

Some strains of Mycobacterium tuberculosis seem to be able to avoid host defense systems. Here the authors stratify patients by severity of tuberculosis and find correlations with the level of IL-1β production by macrophages exposed to these isolates.

Understanding the microscopic variability of CMOS spin qubits is crucial for developing scalable quantum processors. Here the authors report a combined experimental and numerical study of the effect of interface roughness on variability of quantum dot spin qubits formed at the Si/SiO₂ interface.

High-performance all-electrical control is a prerequisite for scalable silicon quantum computing. The switchable interaction between spins and orbital motion of electrons in silicon quantum dots now enables the electrical control of a spin qubit with high fidelity and speed, without the need for integrating a micromagnet.

Quantum dots are often referred to as “artificial atoms” as they create zero-dimensional traps for electrons, with characteristic atom-like spectra. Leon et al. demonstrate that higher shell and orbital states of a multi-electron silicon quantum dot with better control fidelity than single electron dots.

Global control of a qubits using a single microwave field is a promising strategy for scalable quantum computing. Here the authors demonstrate individual addressability vial local electrodes and two-qubit gates in an array of Si quantum dot spin qubits dressed by a global microwave field and driven on-resonance.

For solid-state qubits, the material environment hosts sources of errors that vary in time and space. This systematic analysis of errors affecting high-fidelity two-qubit gates in silicon can inform the design of large-scale quantum computers.

Initialization and operation of spin qubits in silicon above 1 K reach fidelities sufficient for fault-tolerant operations at these temperatures.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Long-range coherent spin-qubit transfer between semiconductor quantum dots requires understanding and control over associated errors. Here, the authors achieve high-fidelity coherent state transfer in a Si double quantum dot, underpinning the prospects of a large-scale quantum computer.

A scalable silicon quantum processor unit cell made of two qubits confined to quantum dots operates at about 1.5 K, achieving 98.6% single-qubit gate fidelities and a 2 μs coherence time.

Hole-spin qubits based on semiconductor quantum dots offer potential advantages over their electron-spin counterparts, such as fast qubit control and enhanced coherence times. Liles et al. report a hole-based singlet-triplet spin qubit in planar Si MOS device and develop a model to describe its dynamics.

Encoding information redundantly in a three-spin-qubit silicon device together with a novel quantum gate can protect against common errors.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

Sebastien Gagneux and colleagues analyze a global collection of Mycobacterium tuberculosis clinical isolates to classify sublineages by phylogeography. They find globally distributed ‘generalist’ and geographically restricted ‘specialist’ sublineages of lineage 4, indicating that different evolutionary strategies were adopted to succeed in various ecological niches.

Here, the authors describe the mechanisms by which innate immune cells contribute to acute kidney injury, the transition from acute kidney injury to chronic kidney disease, and the progression of chronic kidney disease. They also discuss potential therapeutic strategies that target the innate immune system.

ATTR amyloidosis causes heart failure through the accumulation of misfolded transthyretin in cardiac muscle. Here the authors report a mouse model of ATTR amyloidosis and demonstrate the involvement of protease activity in ATTR amyloid deposition.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

Podocytes reside in a unique microenvironment where they are exposed to mechanical force and a variety of molecules that cross the filtration barrier. This Review describes the various mechanisms by which podocytes sense and respond to their complex environment and how these processes affect glomerular and kidney health.

In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.