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Wang and colleagues present DGAT, a computational method that predicts spatial protein expression from transcriptomics data alone, enabling protein-level analysis and revealing tissue organisation across diverse biological contexts.

The authors report a resonant inelastic x-ray scattering study of superconducting Sm-based infinite-layer nickelate thin films. Despite the two-fold enhancement of T_c in the Sm-based nickelates compared to their Pr-based counterparts, they find that the effective in-plane exchange coupling strength is reduced by approximately 20%.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Clinical success of fecal microbiota transplantation depends on donor microbe engraftment. Here, the authors show that inorganic nitrogen utilization capacity drives gut microbiome remodeling and that boosting this function enhances donor microbe engraftment and improved colitis treatment in mice.

Measuring antibody levels is crucial to assess population immunity and guide vaccine development. Here, the authors develop a Bayesian hierarchical model (BHM) that provides accurate and robust estimates of neutralizing antibody titers.

Perseveration – repeating one choice when others would generate larger rewards – is a common behavior, but neither its purpose nor neuronal mechanisms are understood. Here the authors demonstrate a neural correlate and causal role of dorsal prefrontal cortex, specifically anterior supplementary motor cortex, in perseveration in mice performing a dynamic reward learning task.

Satellite radar altimetry is used to map the wave-affected Antarctic marginal ice zone-the outer icepack where waves penetrate the ice- providing a decade-long climatology of its extent and knowledge on its drivers.

Phenotype switching is a key driver of melanoma progression and therapy resistance. Here, the authors identify the small MAF family transcription factor MAFG as a critical regulator of microphthalmia-associated transcription factor (MITF) activity and melanoma cell state plasticity through binding MITF to redirect its genomic occupancy and modulate its transcriptional programming.

Tin-lead perovskites enable tandem devices to surpass the Shockley-Queisser limit, but oxidation of tin severely degrades film quality and performance. Jiang et al. stabilize bulk and surface with two natural antioxidants, boosting both single- and tandem-device efficiency and stability.

Here they assemble a cross-species single-cell transcriptomic atlas of mammalian placentas and show that trophoblast diversification underlies placental evolution, while identifying TGIF1 as a regulator associated with preeclampsia and pregnancy loss.

Retroelement transcripts-derived double-stranded RNAs (dsRNAs) can trigger innate immune responses in cancer through a process known as viral mimicry. Here the authors show that METTL3, the writer of m6A modification, regulates the abundance of steady-state dsRNAs and it could be targeted together with DNA methyltransferases to enhance viral mimicry in colorectal cancer therapy.

Fu and colleagues present LUNAR, a self-supervised neural-physics method that reconstructs 3D molecular positions and optical aberrations directly from raw microscopy data, enabling calibration-free super-resolution imaging in complex biological samples.

PDS5B, a cohesin regulatory protein, is shown to bind DNA and enhance the RAD51 recombinase in the promotion of DNA strand exchange and protection of DNA from MRE11 RAD50-NBS1. Here the authors use biochemical and cellular analyses to reveal that DNA binding by PDS5B is essential for DNA damage repair and the preservation of stressed DNA replication forks.

Here, the authors provide a framework to map glucuronidated metabolites and show that gut microbes shape their distribution across the body, with findings in mice supported by human data, where colonization and diet influence glucuronidation patterns.

Glioblastomas represent a malignant brain tumour with high mortality rate due to resistance to traditional therapies. Here the authors propose a strategy of delivering an IL-15 superagonist IL-15-receptor-linked fusion protein by a non-lytic replicating retrovirus directly to the tumours, which shows high therapeutic efficacy in a mouse model.

Nonreciprocal magneto-transport is often attributed to Zeeman-driven mechanisms. Here, the authors identify Lorentz skew scattering nonreciprocal magneto-transport in BiTeBr which emerges from the cooperation of classical Lorentz force and quantum skew scattering.

Triticum urartu is the diploid progenitor of polyploid wheat A subgenome. Here, the authors report an improved genome assembly of T. urartu and uncover a lipoxygenase gene that shapes T. urartu gene pools and their contributions to polyploid wheat A subgenome by regulating growth-defense trade offs.

SUCCEED is a supervised multi-task DNA foundation model pretrained on 6,389 ENCODE tracks. It integrates CNN and Transformer architectures to model local motifs and long-range dependencies, enabling prediction of genomic regulatory features across tasks and cell types.

This study develops an urban climate-energy modeling framework to assess community energy resilience under climate risks, revealing increased disparities in New York City and supporting resilient and equitable energy system planning.

Protein-based bioplastics suffer from poor mechanical properties, limiting their use. Here, the authors report a coacervation based processing method for maize-derived zein protein which encourages β-sheet formation through shear-induced alignment, leading to high tensile strength films and fibres.

Molecular characteristics of amniote lineages can inform evolutionary inference. Here, the authors present a single-cell RNA-sequencing atlas of the chicken, which is applied to compare immune cells of chicken, turtle, duck and human, determining similarities and distinctions across amniote immune system evolution.

Neogene lithium isotope records from the Tibetan Plateau suggest that silicate weathering in mountain ranges may not persistently contribute sufficient lithium into the ocean to regulate seawater lithium isotope evolution

The tumor suppressor protein p53 is commonly mutated in cancer and has been challenging for therapeutic reactivation. Here, the authors developed a small molecule chemical inducer of proximity to selectively activate p53 transcription and induce cellular senescence and apoptosis in p53^Y220C cells.

Soil microbes drive ecosystem functions but are vulnerable to environmental stressors triggered by global change. This study reveals that multiple environmental stressors drive community-level restructuring of soil functional microbiomes globally.

Optical frequency comb generation usually relies on Kerr or Pockels nonlinearities. Here, the authors create a Floquet cavity by periodically modulating the resonance, achieving phase-locked Floquet sideband generation under nanowatt power consumption. The produced combs is independent of a pumping threshold and insensitive to pump detuning.

Ants are common soil engineers that influence carbon cycling. This meta-analysis shows that ants increase soil organic carbon storage by 22% and CO₂ emissions by 84%, with effects shaped by species, nesting strategy, and climate.

ZAT-DNA encodes data in A/Z base patterns that PCR erases, ensuring molecular non-replicability. It enables secure 32/64-bit key storage and nanopore retrieval, blocks copying, and protects NFTs. The Babel-DNA hybrid allows selective access to multiple encrypted datasets from a single DNA pool using unique ZAT-DNA keys.

Applying the right to be forgotten to electronic health records that have been used to train artificial intelligence models could compromise model accuracy and fairness. Here, the authors develop a machine unlearning model that aims to remove data whilst preserving algorithmic fairness across subgroups.

Large numbers of studies performed over the past three decades have reported candidate blood biomarkers with seemingly high levels of diagnostic performance for stroke recognition. Here, the authors show that these results may largely be artifacts of underlying translational confounds.

Urban green spaces are linked to better human health, however whether lant species heterogeneity also influences better health outcomes remains unclear. Here, Zhao et al., propose the beta-diversity hypothesis, using data from 72 neighborhoods across Shanghai.

Autophagic activity has a protective role in Alzheimer’s disease in mice. Here the authors investigate the role of autophagy-initiating protein ULK1 and report that its overexpression stimulates autophagic flux, reduces amyloid and tau pathology and delays cognitive decline.

The gut microbial-derived metabolite HMB induces hepatic SNHG9, which suppresses MYC translation via IMP2, thereby derepressing MAS expression. MAS promotes protective autophagy, and HMB supplementation mitigates acetaminophen-induced liver injury.

Natural silk, mechanically strong and biodegradable, offers great potential for sustainable functional materials. Here the authors present a simple thermomechanical method for fabricating high-performance structural and optically active materials directly from silk fibres.

PI3K has emerged as a potential therapeutic target for serious endometrial cancer but efficacy and duration of response is limited. Here, the authors develop a serous endometrial cancer murine model driven by PIK3CA mutation, TP53 loss and MYC overexpression, identifying FGFR pathway activation as a driver of PI3K-targeted therapeutic resistance and immune suppression.

The success of KRAS G12C mutation specific inhibitors in patients with KRAS-driven tumours is limited by the emergence of acquired resistance. Here, the authors characterise olomorasib, a next-generation covalent KRAS G12C-mutant inhibitor, demonstrating efficacy in the presence of clinically relevant resistance mutations in preclinical KRAS-driven cancer models.

Enhancer-promoter configuration influences transcription, but its kinetic basis was unclear. Here, the authors use live imaging in Drosophila embryos to show that distance controls initiation, while downstream enhancers reduce mRNA output by ~70% by destabilising interactions.

Understanding the subcellular distribution of RNA-binding proteins can shed light on their structural and functional features. Here, the authors map RNA-binding proteins across cellular compartments, revealing hierarchies and atypical functions.

Using pear as a study system, the biosynthetic pathway of acetophenones has been elucidated: naturally impaired side-chain shortening of aromatic 3-ketoacyl-CoAs leads them to undergo hydrolysis, followed by decarboxylation, to yield acetophenones.

Researchers have found that extreme hot-wet weather in 2024 triggered a spike in ecosystem respiration, mainly in tropical non-forests, significantly reducing the year’s land carbon sink and pushing the atmospheric CO2 growth rate to a record high.

According to a data model analysis, dark brown carbon emitted by wildfires exerts radiative effects that can rival or exceed those of black carbon, extending into mid- and high-latitude regions, including the Arctic.

Core needle biopsy is the gold standard for cancer diagnostics, but may lead to pain and risk of complications. Here, the authors introduce shock-scattering micro-histotripsy cavitation of micro-liter volumes of tumor to acquire a thousand-fold enhancement of biomarkers via fine-needle aspiration.

CheckMate 650 was a multicohort phase 2 trial designed to study the safety and clinical activity of nivolumab plus ipilimumab combination therapy in patients with metastatic castration-resistant prostate cancer. Here the authors report the results of the randomized portion of the trial, including three different immunotherapy treatment cohorts and a current standard-of-care chemotherapy cohort (cabazitaxel).

The crystal phase of metal nanocatalysts critically influences their catalytic performance, yet the atomic-scale mechanisms underlying their phase-dependent reactivity remain poorly understood. Using operando gas-cell transmission electron microscopy, here the authors directly correlate the crystal structure of Ru nanoparticles with their catalytic behavior during CO oxidation.

Polygenic risk scores vary with genetic ancestry. Here, the authors develop a framework to calibrate for genetic ancestry in these scores that leverages admixture analysis, separating out the ancestry-specific component of polygenic risk scores.

URM1 is an ancient protein modifier whose mechanism in human cells has been unclear. Here, the authors show that NAE1/UBA3 and UBE2M drive URM1 modification, especially during oxidative stress, and that pathway inhibition sensitizes liver cancer cells to cisplatin.

2D photodetectors hold potential for several applications, but they are normally limited by an intrinsic sensitivity-speed trade-off. Here, the authors report the realization of 2D PdPSe/WSe₂ photodetectors with a monolayer tungsten oxyselenide interlayer, leading to a detectivity up to 3.78 × 10¹⁵ Jones and a bandwidth of 0.055 GHz in the visible range.