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Showing 1–50 of 103 results

Advanced filters: Author: Akira Fujiwara Clear advanced filters

Expected shape distribution of asteroids obtained from laboratory impact experiments

AKIRA FUJIWARA
GORO KAMIMOTO
AKIMASA TSUKAMOTO
Research13 Apr 1978
Nature

Volume: 272, P: 602-603
Power generator driven by Maxwell’s demon

The study of Maxwell's demon provides a link between information thermodynamics and modern electronics. Using integrated nanometer-scale transistors in a single electron box configuration, Chidaet al., demonstrate the extraction of electrical power by Maxwell’s demon.

Kensaku Chida
Samarth Desai
Akira Fujiwara
ResearchOpen Access16 May 2017
Nature Communications

Volume: 8, P: 1-7
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Mobility and ESR Spectra of Free Radicals Trapped in Irradiated Urea–Poly(ethylene oxide) Complex

Shigetaka Shimada
Akira Fujiwara
Hisatsugu Kashiwabara
Research01 Aug 1981
Polymer Journal

Volume: 13, P: 769-775
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

Yoshiya Kawaguchi
Toshihiro Okamoto
Akira Kakizuka
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 221-228
An unnatural hydrophobic base pair system: site-specific incorporation of nucleotide analogs into DNA and RNA

Ichiro Hirao
Michiko Kimoto
Shigeyuki Yokoyama
Research23 Aug 2006
Nature Methods

Volume: 3, P: 729-735
The Effect of Temperature on Optical and Viscoelastic Properties of a Homogeneous Thermotropic Liquid Crystalline Polymer

Paul Driscoll
Ken-ichi Fujiwara
Robert W Lenz
Research01 Apr 1988
Polymer Journal

Volume: 20, P: 351-356
Maternal copy number variations detected by noninvasive prenatal testing in Japanese women

Kaku Masuda
Hiroyuki Mishima
Kiyonori Miura
Research13 Jan 2026
Journal of Human Genetics

P: 1-8
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Breaking the Landauer limit

A diode made of a self-assembly monolayer with ferrocenyl termini shows an on/off ratio of ∼10⁵.

Nicolas Clement
Akira Fujiwara
News & Views03 Jul 2017
Nature Nanotechnology

Volume: 12, P: 725-726
Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

Clare Bailey
Clemens Lange
Vasileios Konidaris
ResearchOpen Access16 Jan 2026
Eye

P: 1-4
Publisher Correction: Power generator driven by Maxwell’s demon

Kensaku Chida
Samarth Desai
Akira Fujiwara
Amendments and CorrectionsOpen Access27 Mar 2023
Nature Communications

Volume: 14, P: 1
Evaluating blood pressure targets in chronic kidney disease: a systematic review and meta-analysis

Kazuhiro Tada
Akira Fujiwara
Naoki Nakagawa
Research20 Jun 2025
Hypertension Research

Volume: 48, P: 2358-2367
Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV/SIV group

Masashi Fukasawa
Tomoyuki Miura
Masanori Hayami
Research02 Jun 1988
Nature

Volume: 333, P: 457-461
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels

Functional and structural characterization of rhodopsin-bestrophin fusion proteins from marine algae unveils the existence of giant light-sensitive anion channels with unusual biophysical properties.

Andrey Rozenberg
Igor Kaczmarczyk
Moran Shalev-Benami
Research16 Jun 2022
Nature Structural & Molecular Biology

Volume: 29, P: 592-603
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Impact of COVID-19 pandemic on bone and soft tissue sarcoma patients’ consultation and diagnosis

Ryunosuke Oyama
Makoto Endo
Yasuharu Nakashima
ResearchOpen Access04 Sept 2024
Scientific Reports

Volume: 14, P: 1-8
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

In vitro studies suggest that the adaptor TANK is needed for the production of type 1 interferon. Using TANK-deficient mice, Akira and colleagues instead find that TANK negatively regulates Toll-like receptor and B cell antigen receptor signaling in vivo.

Tatsukata Kawagoe
Osamu Takeuchi
Shizuo Akira
Research09 Aug 2009
Nature Immunology

Volume: 10, P: 965-972
Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice

Akira Goto
Kazufumi Matsushita
Jean-Marc Reichhart
Research09 Dec 2007
Nature Immunology

Volume: 9, P: 97-104
Relation between brain temperature and white matter damage in subacute carbon monoxide poisoning

Shunrou Fujiwara
Yoshichika Yoshioka
Takaaki Beppu
ResearchOpen Access07 Nov 2016
Scientific Reports

Volume: 6, P: 1-8
Picosecond coherent electron motion in a silicon single-electron source

The internal electron dynamics of submicrometre devices are hard to resolve because of bandwidth limitations of current measurement techniques. Here, the authors sample the 250 GHz coherent oscillation of a single-electron wave packet inside a quantum dot at 4.2 K employing a resonant level.

Gento Yamahata
Sungguen Ryu
Masaya Kataoka
Research04 Nov 2019
Nature Nanotechnology

Volume: 14, P: 1019-1023
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Manipulation of elementary charge in a silicon charge-coupled device

Akira Fujiwara
Yasuo Takahashi
Research29 Mar 2001
Nature

Volume: 410, P: 560-562
Discriminability of selected periods III‒IV elements in photon-counting computed tomography using a pixelated CdTe detector

Kengo Shibuya
Shunya Nakasone
Jun Kawarabayashi
ResearchOpen Access28 Nov 2025
Scientific Reports

Volume: 15, P: 1-11
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

The stability of interleukin 6 transcripts is negatively regulated by the RNAse regnase-1. Akira and colleagues show that regnase-1 is targeted for degradation by phosphorylation mediated by the kinase IKK, which allows more interleukin 6 production.

Hidenori Iwasaki
Osamu Takeuchi
Shizuo Akira
Research30 Oct 2011
Nature Immunology

Volume: 12, P: 1167-1175
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Macrophages can be divided into two subsets, M1 and M2, which have crucial differences in their function. Akira and colleagues identify the histone demethylase Jmjd3 as a key factor in M2 development.

Takashi Satoh
Osamu Takeuchi
Shizuo Akira
Research22 Aug 2010
Nature Immunology

Volume: 11, P: 936-944
A Comparison of Optical Light Transmission and Dynamic Viscoelastic Properties for Determining Transitions in Thermotropic Liquid Crystalline Polymers

Paul Driscoll
Toshiro Masuda
Subrata Bhattacharya
Research01 Jul 1990
Polymer Journal

Volume: 22, P: 609-613
Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women

Tomoki Kawahara
Nobutoshi Nawa
Takeo Fujiwara
Research21 Mar 2025
Journal of Human Genetics

Volume: 70, P: 265-273
Universality of non-equilibrium fluctuations in strongly correlated quantum liquids

Quantum liquids at equilibrium follow Fermi liquid theory, but less is known about non-equilibrium conditions. Carbon nanotubes, which exhibit universal scaling behaviour, provide a testbed for many-body physics beyond equilibrium.

Meydi Ferrier
Tomonori Arakawa
Kensuke Kobayashi
Research23 Nov 2015
Nature Physics

Volume: 12, P: 230-235
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene

Tomoya O. Akama
Kohji Nishida
Michiko N. Fukuda
Research01 Oct 2000
Nature Genetics

Volume: 26, P: 237-241
Suppression of B function strongly supports the modified ABCE model in Tricyrtis sp. (Liliaceae)

Masahiro Otani
Ahmad Sharifi
Masaru Nakano
ResearchOpen Access15 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Gigahertz single-trap electron pumps in silicon

Devices that generate single electrons are crucial for a precise definition of the ampere—the SI unit for electrical current. Yamahata et al. now demonstrate a silicon-based transistor that can accurately emit lone electrons at a rate of over 3 billion per second.

Gento Yamahata
Katsuhiko Nishiguchi
Akira Fujiwara
ResearchOpen Access06 Oct 2014
Nature Communications

Volume: 5, P: 1-7
Perinatal outcomes of fetal CNVs detected by genome-wide non-invasive prenatal testing in Japan

Yuka Yamashita
Nahoko Shirato
Akihiko Sekizawa
Research26 Sept 2025
Journal of Human Genetics

Volume: 71, P: 81-89
Transvalencin Z, a New Antimicrobial Compound with Salicylic Acid Residue from Nocardia transvalensis IFM 10065

Akira Mukai
Toshio Fukai
Yuzuru Mikami
Research01 Jun 2006
The Journal of Antibiotics

Volume: 59, P: 366-369
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Effects of blood pressure lowering in patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis

Hiroaki Kawano
Akira Fujiwara
Hisatomi Arima
Research05 Apr 2019
Hypertension Research

Volume: 42, P: 504-513
Angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers in hypertensive patients with myocardial infarction or heart failure: a systematic review and meta-analysis

Toshio Ohtsubo
Rei Shibata
Hisatomi Arima
Research05 Apr 2019
Hypertension Research

Volume: 42, P: 641-649
Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells

Min-Seok Kim
Tsutomu Takahashi
Gi-Wook Hwang
ResearchOpen Access15 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
Effects of lowering diastolic blood pressure to <80 mmHg on cardiovascular mortality and events in patients with coronary artery disease: a systematic review and meta-analysis

Ryuji Okamoto
Eita Kumagai
Hisatomi Arima
Research05 Apr 2019
Hypertension Research

Volume: 42, P: 650-659
Establishment of a model of sentinel lymph node metastasis using immunodeficient swine

Toshiaki Kurihara
Sachiko Matsuda
Yuko Kitagawa
ResearchOpen Access28 May 2019
Scientific Reports

Volume: 9, P: 1-9
A retrospective analysis of haplo-identical HLA-mismatch hematopoietic transplantation without posttransplantation cyclophosphamide for GVHD prophylaxis in patients with adult T-cell leukemia–lymphoma

Makoto Yoshimitsu
Atae Utsunomiya
Koji Kato
Research13 Dec 2018
Bone Marrow Transplantation

Volume: 54, P: 1266-1274
A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

Idiopathic pulmonary fibrosis is associated with increased abundance of Staphylococcus and Streptococcus in the lungs. Here, the authors identify a Staphylococcus nepalensis-derived peptide, named corisin, to induce apoptosis of lung epithelial cells and exacerbation of pulmonary fibrosis in mice.

Corina N. D’Alessandro-Gabazza
Tetsu Kobayashi
Esteban C. Gabazza
ResearchOpen Access24 Mar 2020
Nature Communications

Volume: 11, P: 1-17
Electron aspirator using electron–electron scattering in nanoscale silicon

Power dissipation is usually unavoidable in transistor channels due to the inelastic scattering of electrons. Here, Firdaus et al. propose a nanoscaled silicon electron-aspirator to remove this constraint, which shows enhanced current output by 3 times at 8 K without additional power supply.

Himma Firdaus
Tokinobu Watanabe
Yukinori Ono
ResearchOpen Access17 Dec 2018
Nature Communications

Volume: 9, P: 1-8
Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome

Koji Otani
Toshio Watanabe
Tetsuo Arakawa
ResearchOpen Access02 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Evaluation of Brain Activity Using Near-infrared Spectroscopy in Inflammatory Bowel Disease Patients

Tatsuo Fujiwara
Soichi Kono
Hiromasa Ohira
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-10
High-accuracy current generation in the nanoampere regime from a silicon single-trap electron pump

Gento Yamahata
Stephen P. Giblin
Akira Fujiwara
ResearchOpen Access21 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
Essential function for the kinase TAK1 in innate and adaptive immune responses

Shintaro Sato
Hideki Sanjo
Shizuo Akira
Research25 Sept 2005
Nature Immunology

Volume: 6, P: 1087-1095

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